ID:AF9_HUMAN DESCRIPTION: RecName: Full=Protein AF-9; AltName: Full=ALL1-fused gene from chromosome 9 protein; AltName: Full=Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; AltName: Full=YEATS domain-containing protein 3; SUBUNIT: Interacts with BCOR. Interacts with CBX8. INTERACTION: Q9UHB7:AFF4; NbExp=4; IntAct=EBI-716132, EBI-395282; SUBCELLULAR LOCATION: Nucleus (By similarity). DISEASE: Note=A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with MLL/HRX. The result is a rogue activator protein. SIMILARITY: Contains 1 YEATS domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/AF9.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P42568
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
L13744 - Human AF-9 mRNA, complete cds. BX649194 - Homo sapiens mRNA; cDNA DKFZp686D09204 (from clone DKFZp686D09204). AK301474 - Homo sapiens cDNA FLJ53222 complete cds, highly similar to Protein AF-9. BC036089 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3, mRNA (cDNA clone MGC:33789 IMAGE:5298142), complete cds. AK225957 - Homo sapiens mRNA for myeloid/lymphoid or mixed-lineage leukemia variant, clone: FCC114E07. AK297587 - Homo sapiens cDNA FLJ58676 complete cds, highly similar to Protein AF-9. AK312914 - Homo sapiens cDNA, FLJ93363, highly similar to Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), mRNA. JF432808 - Synthetic construct Homo sapiens clone IMAGE:100074126 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) gene, encodes complete protein. KJ897192 - Synthetic construct Homo sapiens clone ccsbBroadEn_06586 MLLT3 gene, encodes complete protein. KU178189 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia; translocated to 3 isoform 1 (MLLT3) mRNA, partial cds. KU178190 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia; translocated to 3 isoform 3 (MLLT3) mRNA, complete cds, alternatively spliced. AB463323 - Synthetic construct DNA, clone: pF1KB8734, Homo sapiens MLLT3 gene for trithorax homolog, without stop codon, in Flexi system. BC030550 - Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3, mRNA (cDNA clone IMAGE:5212069), containing frame-shift errors. CU690292 - Synthetic construct Homo sapiens gateway clone IMAGE:100019887 5' read MLLT3 mRNA. JD565885 - Sequence 546909 from Patent EP1572962. JD510796 - Sequence 491820 from Patent EP1572962. JD320417 - Sequence 301441 from Patent EP1572962. JD508203 - Sequence 489227 from Patent EP1572962. JD288797 - Sequence 269821 from Patent EP1572962. JD272218 - Sequence 253242 from Patent EP1572962. D16688 - Homo sapiens mRNA for LTG9/MLLT3 protein, partial cds. JD510234 - Sequence 491258 from Patent EP1572962. JD090626 - Sequence 71650 from Patent EP1572962. JD047050 - Sequence 28074 from Patent EP1572962. JD459893 - Sequence 440917 from Patent EP1572962. JD069610 - Sequence 50634 from Patent EP1572962. JD267082 - Sequence 248106 from Patent EP1572962. JD502712 - Sequence 483736 from Patent EP1572962. JD262571 - Sequence 243595 from Patent EP1572962. JD322738 - Sequence 303762 from Patent EP1572962. EF406122 - Homo sapiens MLL/AF9 translocation breakpoint junction sequence. JD371454 - Sequence 352478 from Patent EP1572962. MN238625 - Homo sapiens isolate 5989 KMT2A/MLLT3 fusion protein (KMT2A/MLLT3 fusion) mRNA, partial cds. AK128222 - Homo sapiens cDNA FLJ46355 fis, clone TESTI4049110. JD068375 - Sequence 49399 from Patent EP1572962. JD478328 - Sequence 459352 from Patent EP1572962. JD127196 - Sequence 108220 from Patent EP1572962. JD520328 - Sequence 501352 from Patent EP1572962. JD314278 - Sequence 295302 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P42568 (Reactome details) participates in the following event(s):
R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
