Human Gene MMP11 (ENST00000215743.8_4) from GENCODE V47lift37
  Description: matrix metallopeptidase 11, transcript variant 1 (from RefSeq NM_005940.5)
Gencode Transcript: ENST00000215743.8_4
Gencode Gene: ENSG00000099953.10_11
Transcript (Including UTRs)
   Position: hg19 chr22:24,115,036-24,126,503 Size: 11,468 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr22:24,115,058-24,125,731 Size: 10,674 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:24,115,036-24,126,503)mRNA (may differ from genome)Protein (488 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MMP11_HUMAN
DESCRIPTION: RecName: Full=Stromelysin-3; Short=SL-3; Short=ST3; EC=3.4.24.-; AltName: Full=Matrix metalloproteinase-11; Short=MMP-11; Flags: Precursor;
FUNCTION: May play an important role in the progression of epithelial malignancies.
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (Probable).
TISSUE SPECIFICITY: Specifically expressed in stromal cells of breast carcinomas.
DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
SIMILARITY: Belongs to the peptidase M10A family.
SIMILARITY: Contains 4 hemopexin-like domains.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ST3ID200.html";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp11/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MMP11
Diseases sorted by gene-association score: space motion sickness (16), aleutian mink disease (15), dermatofibrosarcoma protuberans (13), cutaneous fibrous histiocytoma (12), dermis tumor (11), angiomatous meningioma (10), ophthalmomyiasis (9), basal cell carcinoma (7), intervertebral disc disease (5), deafness, autosomal recessive 12 (4), colorectal cancer (4), breast cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.74 RPKM in Cervix - Endocervix
Total median expression: 58.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.3022-0.286 Picture PostScript Text
3' UTR -322.30772-0.417 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000585 - Hemopexin/matrixin
IPR018486 - Hemopexin/matrixin_CS
IPR018487 - Hemopexin/matrixin_repeat
IPR024079 - MetalloPept_cat_dom
IPR001818 - Pept_M10_metallopeptidase
IPR016293 - Pept_M10A_matrix_strom
IPR021190 - Pept_M10A_matrixin
IPR021158 - Pept_M10A_Zn_BS
IPR006026 - Peptidase_Metallo

Pfam Domains:
PF00045 - Hemopexin
PF00413 - Matrixin

SCOP Domains:
50923 - Hemopexin-like domain
55486 - Metalloproteases ("zincins"), catalytic domain

ModBase Predicted Comparative 3D Structure on P24347
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006508 proteolysis
GO:0007275 multicellular organism development
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030574 collagen catabolic process
GO:0045599 negative regulation of fat cell differentiation
GO:0071711 basement membrane organization

Cellular Component:
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0031012 extracellular matrix


-  Descriptions from all associated GenBank mRNAs
  AK125911 - Homo sapiens cDNA FLJ43923 fis, clone TESTI4012448, highly similar to Stromelysin-3 precursor (EC 3.4.24.-).
LF208792 - JP 2014500723-A/16295: Polycomb-Associated Non-Coding RNAs.
AK129792 - Homo sapiens cDNA FLJ26281 fis, clone DMC06771, highly similar to Stromelysin-3 precursor (EC 3.4.24.-).
AK075448 - Homo sapiens cDNA PSEC0140 fis, clone PLACE1005783, highly similar to STROMELYSIN-3 PRECURSOR (EC 3.4.24.-).
X57766 - Human stromelysin-3 mRNA.
BC057788 - Homo sapiens matrix metallopeptidase 11 (stromelysin 3), mRNA (cDNA clone MGC:71622 IMAGE:30348138), complete cds.
MA444369 - JP 2018138019-A/16295: Polycomb-Associated Non-Coding RNAs.
LF322819 - JP 2014500723-A/130322: Polycomb-Associated Non-Coding RNAs.
LF322818 - JP 2014500723-A/130321: Polycomb-Associated Non-Coding RNAs.
JD094721 - Sequence 75745 from Patent EP1572962.
LF322816 - JP 2014500723-A/130319: Polycomb-Associated Non-Coding RNAs.
JD498003 - Sequence 479027 from Patent EP1572962.
JD220632 - Sequence 201656 from Patent EP1572962.
JD219223 - Sequence 200247 from Patent EP1572962.
JD269861 - Sequence 250885 from Patent EP1572962.
JD460665 - Sequence 441689 from Patent EP1572962.
JD137126 - Sequence 118150 from Patent EP1572962.
JD225641 - Sequence 206665 from Patent EP1572962.
DQ399599 - Homo sapiens matrix metalloproteinase 11 (MMP11) mRNA, partial cds.
JD428135 - Sequence 409159 from Patent EP1572962.
LF322815 - JP 2014500723-A/130318: Polycomb-Associated Non-Coding RNAs.
JD486822 - Sequence 467846 from Patent EP1572962.
JD452717 - Sequence 433741 from Patent EP1572962.
JD339549 - Sequence 320573 from Patent EP1572962.
JD388633 - Sequence 369657 from Patent EP1572962.
JD075806 - Sequence 56830 from Patent EP1572962.
JD040383 - Sequence 21407 from Patent EP1572962.
DM110840 - Novel Cancer Marker and Use Thereof.
MA558396 - JP 2018138019-A/130322: Polycomb-Associated Non-Coding RNAs.
MA558395 - JP 2018138019-A/130321: Polycomb-Associated Non-Coding RNAs.
MA558393 - JP 2018138019-A/130319: Polycomb-Associated Non-Coding RNAs.
MA558392 - JP 2018138019-A/130318: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P24347 (Reactome details) participates in the following event(s):

R-HSA-1602484 Activation of proMMP11 by FURIN
R-HSA-1454781 MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin
R-HSA-1592297 Full activation of MMP1
R-HSA-1564112 Collagen type VI degradation by MMP2,9,11
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000215743.1, ENST00000215743.2, ENST00000215743.3, ENST00000215743.4, ENST00000215743.5, ENST00000215743.6, ENST00000215743.7, MMP11_HUMAN, NM_005940, P24347, Q5FX24, Q6PEZ6, Q9UC26, STMY3, uc317cmo.1, uc317cmo.2
UCSC ID: ENST00000215743.8_4
RefSeq Accession: NM_005940.5
Protein: P24347 (aka MMP11_HUMAN or MM11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.