ID:MMP11_HUMAN DESCRIPTION: RecName: Full=Stromelysin-3; Short=SL-3; Short=ST3; EC=3.4.24.-; AltName: Full=Matrix metalloproteinase-11; Short=MMP-11; Flags: Precursor; FUNCTION: May play an important role in the progression of epithelial malignancies. COFACTOR: Binds 1 calcium ion per subunit (By similarity). COFACTOR: Binds 2 zinc ions per subunit (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (Probable). TISSUE SPECIFICITY: Specifically expressed in stromal cells of breast carcinomas. DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. PTM: The precursor is cleaved by a furin endopeptidase (By similarity). SIMILARITY: Belongs to the peptidase M10A family. SIMILARITY: Contains 4 hemopexin-like domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ST3ID200.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp11/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P24347
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
