Human Gene MMP26 (ENST00000380390.6_5) from GENCODE V47lift37
  Description: matrix metallopeptidase 26, transcript variant 1 (from RefSeq NM_021801.5)
Gencode Transcript: ENST00000380390.6_5
Gencode Gene: ENSG00000167346.9_13
Transcript (Including UTRs)
   Position: hg19 chr11:4,726,014-5,013,659 Size: 287,646 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr11:5,009,442-5,013,472 Size: 4,031 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:4,726,014-5,013,659)mRNA (may differ from genome)Protein (261 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MMP26_HUMAN
DESCRIPTION: RecName: Full=Matrix metalloproteinase-26; Short=MMP-26; EC=3.4.24.-; AltName: Full=Endometase; AltName: Full=Matrilysin-2; Flags: Precursor;
FUNCTION: May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
COFACTOR: Calcium (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.
DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
SIMILARITY: Belongs to the peptidase M10A family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MMP26
Diseases sorted by gene-association score: endometrial cancer (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.10 RPKM in Prostate
Total median expression: 0.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.40478-0.310 Picture PostScript Text
3' UTR -39.00187-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024079 - MetalloPept_cat_dom
IPR001818 - Pept_M10_metallopeptidase
IPR021190 - Pept_M10A_matrixin
IPR006026 - Peptidase_Metallo

Pfam Domains:
PF00413 - Matrixin
PF13582 - Metallo-peptidase family M12B Reprolysin-like

SCOP Domains:
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain

ModBase Predicted Comparative 3D Structure on Q9NRE1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006508 proteolysis
GO:0030574 collagen catabolic process
GO:0050728 negative regulation of inflammatory response

Cellular Component:
GO:0005576 extracellular region
GO:0031012 extracellular matrix


-  Descriptions from all associated GenBank mRNAs
  BC101541 - Homo sapiens matrix metallopeptidase 26, mRNA (cDNA clone MGC:126590 IMAGE:8069047), complete cds.
BC101543 - Homo sapiens matrix metallopeptidase 26, mRNA (cDNA clone MGC:126592 IMAGE:8069049), complete cds.
AF291664 - Homo sapiens matrix metalloproteinase-26 (MMP26) mRNA, complete cds.
JD094391 - Sequence 75415 from Patent EP1572962.
AJ251531 - Homo sapiens mRNA for matrilysin-2 (MMP26 gene).
AF230354 - Homo sapiens matrix metalloproteinase MMP-26 mRNA, complete cds.
AF248646 - Homo sapiens matrix metalloproteinase-26 precursor (MMP26) mRNA, complete cds.
KJ894332 - Synthetic construct Homo sapiens clone ccsbBroadEn_03726 MMP26 gene, encodes complete protein.
CQ873842 - Sequence 261 from Patent WO2004076622.
DD413679 - Regulation of Mammalian Cells.
JD062021 - Sequence 43045 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000380390.1, ENST00000380390.2, ENST00000380390.3, ENST00000380390.4, ENST00000380390.5, MMP26_HUMAN, NM_021801, Q3MJ78, Q9GZS2, Q9NR87, Q9NRE1, uc318pol.1, uc318pol.2
UCSC ID: ENST00000380390.6_5
RefSeq Accession: NM_021801.5
Protein: Q9NRE1 (aka MMP26_HUMAN or MM26_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.