ID:MMP8_HUMAN DESCRIPTION: RecName: Full=Neutrophil collagenase; EC=3.4.24.34; AltName: Full=Matrix metalloproteinase-8; Short=MMP-8; AltName: Full=PMNL collagenase; Short=PMNL-CL; Flags: Precursor; FUNCTION: Can degrade fibrillar type I, II, and III collagens. CATALYTIC ACTIVITY: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I. COFACTOR: Binds 3 calcium ions per subunit. COFACTOR: Binds 2 zinc ions per subunit. ENZYME REGULATION: Cannot be activated without removal of the activation peptide. SUBCELLULAR LOCATION: Cytoplasmic granule. Secreted, extracellular space, extracellular matrix (Probable). Note=Stored in intracellular granules. TISSUE SPECIFICITY: Neutrophils. DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. SIMILARITY: Belongs to the peptidase M10A family. SIMILARITY: Contains 4 hemopexin-like domains. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mmp8/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22894
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ904503 - Synthetic construct Homo sapiens clone ccsbBroadEn_13897 MMP8-like gene, encodes complete protein. J05556 - Homo sapiens collagenase mRNA, complete cds. JD043018 - Sequence 24042 from Patent EP1572962. JD530109 - Sequence 511133 from Patent EP1572962. JD494998 - Sequence 476022 from Patent EP1572962. JD368786 - Sequence 349810 from Patent EP1572962. BC144094 - Homo sapiens cDNA clone IMAGE:9052614. JD062142 - Sequence 43166 from Patent EP1572962. JD054199 - Sequence 35223 from Patent EP1572962. JD394247 - Sequence 375271 from Patent EP1572962. AK292659 - Homo sapiens cDNA FLJ76459 complete cds, highly similar to Homo sapiens matrix metallopeptidase 8 (neutrophil collagenase) (MMP8), mRNA. JD506571 - Sequence 487595 from Patent EP1572962. AK303388 - Homo sapiens cDNA FLJ51588 complete cds, highly similar to Neutrophil collagenase precursor (EC 3.4.24.34). JD437273 - Sequence 418297 from Patent EP1572962. JD357064 - Sequence 338088 from Patent EP1572962. AK303511 - Homo sapiens cDNA FLJ51589 complete cds, highly similar to Neutrophil collagenase precursor (EC 3.4.24.34). JD434108 - Sequence 415132 from Patent EP1572962. BC074988 - Homo sapiens matrix metallopeptidase 8 (neutrophil collagenase), mRNA (cDNA clone MGC:104069 IMAGE:30915520), complete cds. BC074989 - Homo sapiens matrix metallopeptidase 8 (neutrophil collagenase), mRNA (cDNA clone MGC:103915 IMAGE:30915305), complete cds. AK313374 - Homo sapiens cDNA, FLJ93905. JD118426 - Sequence 99450 from Patent EP1572962. JD045500 - Sequence 26524 from Patent EP1572962. JD151771 - Sequence 132795 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P22894 (Reactome details) participates in the following event(s):
R-HSA-6798749 Exocytosis of specific granule lumen proteins R-HSA-6798745 Exocytosis of tertiary granule lumen proteins R-HSA-1454781 MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin R-HSA-1454822 Collagen type I degradation by MMP1,2,8,13, PRSS2 R-HSA-1474197 Collagen type II degradation by MMP1,3,8,13,PRSS2 R-HSA-1474213 Collagen type III degradation by MMP1,8,9,13 R-HSA-3791149 Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 R-HSA-1592389 Activation of Matrix Metalloproteinases R-HSA-6798695 Neutrophil degranulation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1442490 Collagen degradation R-HSA-168249 Innate Immune System R-HSA-1474244 Extracellular matrix organization R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
