Human Gene MMS22L (ENST00000683635.1_3) from GENCODE V47lift37
  Description: MMS22 like, DNA repair protein, transcript variant 3 (from RefSeq NM_001350600.2)
Gencode Transcript: ENST00000683635.1_3
Gencode Gene: ENSG00000146263.12_12
Transcript (Including UTRs)
   Position: hg19 chr6:97,590,037-97,731,092 Size: 141,056 Total Exon Count: 25 Strand: -
Coding Region
   Position: hg19 chr6:97,594,682-97,730,353 Size: 135,672 Coding Exon Count: 24 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:97,590,037-97,731,092)mRNA (may differ from genome)Protein (1243 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MMS22_HUMAN
DESCRIPTION: RecName: Full=Protein MMS22-like; AltName: Full=Methyl methanesulfonate-sensitivity protein 22-like;
FUNCTION: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.
SUBUNIT: Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.
INTERACTION: Q9NVP2:ASF1B; NbExp=1; IntAct=EBI-718662, EBI-1055650;
SUBCELLULAR LOCATION: Nucleus. Note=Localizes to DNA damage sites, accumulates at stressed replication forks.
SIMILARITY: Belongs to the MMS22 family. MMS22L subfamily.
SEQUENCE CAUTION: Sequence=CAI16668.1; Type=Erroneous gene model prediction; Sequence=CAI20426.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -62.30197-0.316 Picture PostScript Text
3' UTR -1059.274645-0.228 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF14910 - S-phase genomic integrity recombination mediator, N-terminal
PF14911 - S-phase genomic integrity recombination mediator, C-terminal

SCOP Domains:
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q6ZRQ5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0031297 replication fork processing

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0043596 nuclear replication fork
GO:0035101 FACT complex
GO:0042555 MCM complex


-  Descriptions from all associated GenBank mRNAs
  LF206401 - JP 2014500723-A/13904: Polycomb-Associated Non-Coding RNAs.
AK128060 - Homo sapiens cDNA FLJ46180 fis, clone TESTI4004031.
KU720379 - Homo sapiens MMS22-like DNA repair protein (MMS22L) mRNA, complete cds.
BC160006 - Synthetic construct Homo sapiens clone IMAGE:100063942, MGC:193121 chromosome 6 open reading frame 167 (C6orf167) mRNA, encodes complete protein.
AB385246 - Synthetic construct DNA, clone: pF1KB9492, Homo sapiens C6orf167 gene for C6orf167 protein, complete cds, without stop codon, in Flexi system.
MA441978 - JP 2018138019-A/13904: Polycomb-Associated Non-Coding RNAs.
CR749603 - Homo sapiens mRNA; cDNA DKFZp686C20164 (from clone DKFZp686C20164).
JD088020 - Sequence 69044 from Patent EP1572962.
LF354027 - JP 2014500723-A/161530: Polycomb-Associated Non-Coding RNAs.
JD091377 - Sequence 72401 from Patent EP1572962.
LF354026 - JP 2014500723-A/161529: Polycomb-Associated Non-Coding RNAs.
LF354025 - JP 2014500723-A/161528: Polycomb-Associated Non-Coding RNAs.
LF354021 - JP 2014500723-A/161524: Polycomb-Associated Non-Coding RNAs.
LF354012 - JP 2014500723-A/161515: Polycomb-Associated Non-Coding RNAs.
MA589604 - JP 2018138019-A/161530: Polycomb-Associated Non-Coding RNAs.
MA589603 - JP 2018138019-A/161529: Polycomb-Associated Non-Coding RNAs.
MA589602 - JP 2018138019-A/161528: Polycomb-Associated Non-Coding RNAs.
MA589598 - JP 2018138019-A/161524: Polycomb-Associated Non-Coding RNAs.
MA589589 - JP 2018138019-A/161515: Polycomb-Associated Non-Coding RNAs.
BC142948 - Homo sapiens cDNA clone IMAGE:8860332, with apparent retained intron.
LF353986 - JP 2014500723-A/161489: Polycomb-Associated Non-Coding RNAs.
LF353984 - JP 2014500723-A/161487: Polycomb-Associated Non-Coding RNAs.
BC110860 - Homo sapiens chromosome 6 open reading frame 167, mRNA (cDNA clone IMAGE:6527435), with apparent retained intron.
LF353982 - JP 2014500723-A/161485: Polycomb-Associated Non-Coding RNAs.
BX538214 - Homo sapiens mRNA; cDNA DKFZp686I23109 (from clone DKFZp686I23109).
JD285013 - Sequence 266037 from Patent EP1572962.
CR749822 - Homo sapiens mRNA; cDNA DKFZp781C2113 (from clone DKFZp781C2113).
JD237725 - Sequence 218749 from Patent EP1572962.
LF353977 - JP 2014500723-A/161480: Polycomb-Associated Non-Coding RNAs.
LF353969 - JP 2014500723-A/161472: Polycomb-Associated Non-Coding RNAs.
LF353967 - JP 2014500723-A/161470: Polycomb-Associated Non-Coding RNAs.
JD295075 - Sequence 276099 from Patent EP1572962.
JD507175 - Sequence 488199 from Patent EP1572962.
JD523299 - Sequence 504323 from Patent EP1572962.
MA589563 - JP 2018138019-A/161489: Polycomb-Associated Non-Coding RNAs.
MA589561 - JP 2018138019-A/161487: Polycomb-Associated Non-Coding RNAs.
MA589559 - JP 2018138019-A/161485: Polycomb-Associated Non-Coding RNAs.
MA589554 - JP 2018138019-A/161480: Polycomb-Associated Non-Coding RNAs.
MA589546 - JP 2018138019-A/161472: Polycomb-Associated Non-Coding RNAs.
MA589544 - JP 2018138019-A/161470: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf167 , D6R9Y8, D6RBQ4, E1P529, MMS22L , MMS22_HUMAN, NM_001350600, Q5THT2, Q68CQ6, Q68D32, Q6ZRQ5, uc330lro.1, uc330lro.2
UCSC ID: ENST00000683635.1_3
RefSeq Accession: NM_001350599.2
Protein: Q6ZRQ5 (aka MMS22_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.