ID:MOB1A_HUMAN DESCRIPTION: RecName: Full=MOB kinase activator 1A; AltName: Full=Mob1 alpha; Short=Mob1A; AltName: Full=Mob1 homolog 1B; AltName: Full=Mps one binder kinase activator-like 1B; FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. SUBUNIT: Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. INTERACTION: O95835:LATS1; NbExp=2; IntAct=EBI-748229, EBI-444209; Q9NRM7:LATS2; NbExp=2; IntAct=EBI-748229, EBI-3506895; Q15208:STK38; NbExp=2; IntAct=EBI-748229, EBI-458376; TISSUE SPECIFICITY: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. PTM: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. SIMILARITY: Belongs to the MOB1/phocein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H8S9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9H8S9 (Reactome details) participates in the following event(s):
R-HSA-2028629 Phosphorylation of MOB1A and B by p-STK4 (p-MST1) R-HSA-2028635 Phosphorylation of MOB1A and B by p-STK3 (p-MST2) R-HSA-2028670 Phosphorylation of MOB1A and B by p-STK4(MST1)/N R-HSA-2028675 Phosphorylation of MOB1A and B by p-STK3(MST2)/N R-HSA-2028626 Phosphorylated MOB1A proteins associate with LATS proteins R-HSA-2028555 Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) R-HSA-2028589 Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) R-HSA-2028673 Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N R-HSA-2028679 Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N R-HSA-2028598 Phosphorylation of YAP by LATS1 R-HSA-2060328 Phosphorylation of WWTR1 (TAZ) by LATS1 R-HSA-2028583 Phosphorylation of YAP by LATS2 R-HSA-2028661 Phosphorylation of WWTR1 (TAZ) by LATS2 R-HSA-2028269 Signaling by Hippo R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
