ID:MOG_HUMAN DESCRIPTION: RecName: Full=Myelin-oligodendrocyte glycoprotein; Flags: Precursor; FUNCTION: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. SUBUNIT: Homodimer (By similarity). May form heterodimers between the different isoforms. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Multi-pass membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. DISEASE: Defects in MOG are the cause of narcolepsy type 7 (NRCLP7) [MIM:614250]. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG). WEB RESOURCE: Name=Wikipedia; Note=Myelin oligodendrocyte glycoprotein entry; URL="http://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16653
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
