Human Gene MOS (ENST00000311923.1_6) from GENCODE V47lift37
  Description: MOS proto-oncogene, serine/threonine kinase (from RefSeq NM_005372.1)
Gencode Transcript: ENST00000311923.1_6
Gencode Gene: ENSG00000172680.1_8
Transcript (Including UTRs)
   Position: hg19 chr8:57,025,501-57,026,541 Size: 1,041 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr8:57,025,501-57,026,541 Size: 1,041 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:57,025,501-57,026,541)mRNA (may differ from genome)Protein (346 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MOS_HUMAN
DESCRIPTION: RecName: Full=Proto-oncogene serine/threonine-protein kinase mos; EC=2.7.11.1; AltName: Full=Oocyte maturation factor mos; AltName: Full=Proto-oncogene c-Mos;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
TISSUE SPECIFICITY: Expressed specifically in testis during spermatogenesis.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MOS
Diseases sorted by gene-association score: sarcoma (10)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.81 RPKM in Testis
Total median expression: 1.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on P00540
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000212 meiotic spindle organization
GO:0006325 chromatin organization
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
GO:0043410 positive regulation of MAPK cascade
GO:0046777 protein autophosphorylation
GO:0051296 establishment of meiotic spindle orientation
GO:1902103 negative regulation of metaphase/anaphase transition of meiotic cell cycle

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC069569 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:97024 IMAGE:7262233), complete cds.
BC106737 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:119962 IMAGE:40016104), complete cds.
BC106738 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone MGC:119963 IMAGE:40016106), complete cds.
BC069590 - Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog, mRNA (cDNA clone IMAGE:7262245), partial cds.
HQ447500 - Synthetic construct Homo sapiens clone IMAGE:100070836; CCSB013876_01 v-mos Moloney murine sarcoma viral oncogene homolog (MOS) gene, encodes complete protein.
KJ891635 - Synthetic construct Homo sapiens clone ccsbBroadEn_01029 MOS gene, encodes complete protein.
KJ905228 - Synthetic construct Homo sapiens clone ccsbBroadEn_14699 MOS gene, encodes complete protein.
AB464742 - Synthetic construct DNA, clone: pF1KB9834, Homo sapiens MOS gene for v-mos Moloney murine sarcoma viral oncogene homolog, without stop codon, in Flexi system.
AY279177 - Homo sapiens oncogene MOS-like gene, partial sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: MOS , MOS_HUMAN, NM_005372, P00540, Q3KPG9, Q3KPH0, uc317pcp.1, uc317pcp.2
UCSC ID: ENST00000311923.1_6
RefSeq Accession: NM_005372.1
Protein: P00540 (aka MOS_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.