Human Gene MOSPD2 (ENST00000380492.8_7) from GENCODE V47lift37
  Description: motile sperm domain containing 2, transcript variant 1 (from RefSeq NM_152581.4)
Gencode Transcript: ENST00000380492.8_7
Gencode Gene: ENSG00000130150.12_11
Transcript (Including UTRs)
   Position: hg19 chrX:14,891,543-14,940,449 Size: 48,907 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chrX:14,891,651-14,937,931 Size: 46,281 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:14,891,543-14,940,449)mRNA (may differ from genome)Protein (518 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MSPD2_HUMAN
DESCRIPTION: RecName: Full=Motile sperm domain-containing protein 2;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Contains 1 CRAL-TRIO domain.
SIMILARITY: Contains 1 MSP domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.40 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 188.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.80108-0.304 Picture PostScript Text
3' UTR -536.402518-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001251 - CRAL-TRIO_dom
IPR011074 - CRAL/TRIO_N_dom
IPR000535 - Major_sperm
IPR008962 - PapD-like

Pfam Domains:
PF00635 - MSP (Major sperm protein) domain
PF00650 - CRAL/TRIO domain
PF13716 - Divergent CRAL/TRIO domain

SCOP Domains:
46938 - CRAL/TRIO N-terminal domain
49354 - PapD-like
52087 - CRAL/TRIO domain

ModBase Predicted Comparative 3D Structure on Q8NHP6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006935 chemotaxis
GO:0043312 neutrophil degranulation
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035579 specific granule membrane


-  Descriptions from all associated GenBank mRNAs
  LF211725 - JP 2014500723-A/19228: Polycomb-Associated Non-Coding RNAs.
LP896560 - Sequence 1424 from Patent EP3253886.
BC030641 - Homo sapiens motile sperm domain containing 2, mRNA (cDNA clone MGC:26706 IMAGE:4821861), complete cds.
AL832230 - Homo sapiens mRNA; cDNA DKFZp686C1553 (from clone DKFZp686C1553).
JD083958 - Sequence 64982 from Patent EP1572962.
AK315781 - Homo sapiens cDNA, FLJ96897.
JD116460 - Sequence 97484 from Patent EP1572962.
EU176782 - Synthetic construct Homo sapiens clone IMAGE:100011560; FLH196413.01L; RZPDo839A06256D motile sperm domain containing 2 (MOSPD2) gene, encodes complete protein.
LF383150 - JP 2014500723-A/190653: Polycomb-Associated Non-Coding RNAs.
AK093075 - Homo sapiens cDNA FLJ35756 fis, clone TESTI2004687.
AX747905 - Sequence 1430 from Patent EP1308459.
LF383146 - JP 2014500723-A/190649: Polycomb-Associated Non-Coding RNAs.
AL834345 - Homo sapiens mRNA; cDNA DKFZp761K0315 (from clone DKFZp761K0315).
JD562634 - Sequence 543658 from Patent EP1572962.
AK057941 - Homo sapiens cDNA FLJ25212 fis, clone REC08087.
JD296417 - Sequence 277441 from Patent EP1572962.
JD359497 - Sequence 340521 from Patent EP1572962.
JD440946 - Sequence 421970 from Patent EP1572962.
JD397459 - Sequence 378483 from Patent EP1572962.
JD545735 - Sequence 526759 from Patent EP1572962.
JD469596 - Sequence 450620 from Patent EP1572962.
JD550965 - Sequence 531989 from Patent EP1572962.
JD566505 - Sequence 547529 from Patent EP1572962.
JD244995 - Sequence 226019 from Patent EP1572962.
JD092962 - Sequence 73986 from Patent EP1572962.
JD302559 - Sequence 283583 from Patent EP1572962.
JD086314 - Sequence 67338 from Patent EP1572962.
JD323576 - Sequence 304600 from Patent EP1572962.
JD550628 - Sequence 531652 from Patent EP1572962.
JD082539 - Sequence 63563 from Patent EP1572962.
LF383140 - JP 2014500723-A/190643: Polycomb-Associated Non-Coding RNAs.
MA618727 - JP 2018138019-A/190653: Polycomb-Associated Non-Coding RNAs.
MA618723 - JP 2018138019-A/190649: Polycomb-Associated Non-Coding RNAs.
MA618717 - JP 2018138019-A/190643: Polycomb-Associated Non-Coding RNAs.
MA447302 - JP 2018138019-A/19228: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8NHP6 (Reactome details) participates in the following event(s):

R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000380492.1, ENST00000380492.2, ENST00000380492.3, ENST00000380492.4, ENST00000380492.5, ENST00000380492.6, ENST00000380492.7, MOSPD2 , MSPD2_HUMAN, NM_152581, Q8N3H2, Q8NA83, Q8NHP6, uc318ppz.1, uc318ppz.2
UCSC ID: ENST00000380492.8_7
RefSeq Accession: NM_152581.4
Protein: Q8NHP6 (aka MSPD2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.