Human Gene MOV10 (ENST00000369645.6_3) from GENCODE V47lift37
  Description: Mov10 RISC complex RNA helicase, transcript variant 4 (from RefSeq NM_001321324.2)
Gencode Transcript: ENST00000369645.6_3
Gencode Gene: ENSG00000155363.19_5
Transcript (Including UTRs)
   Position: hg19 chr1:113,217,281-113,243,361 Size: 26,081 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg19 chr1:113,217,535-113,243,129 Size: 25,595 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:113,217,281-113,243,361)mRNA (may differ from genome)Protein (1003 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MOV10_HUMAN
DESCRIPTION: RecName: Full=Putative helicase MOV-10; EC=3.6.4.13; AltName: Full=Moloney leukemia virus 10 protein;
FUNCTION: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA- mediated cleavage of complementary mRNAs by RISC. Also required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBUNIT: Interacts with DICER1, EIF2C1/AGO1, EIF2C2/AGO2, EIF6 and TARBP2. Associates with the 60S ribosome. Interacts with the human hepatitis delta virus (HDV) antigen HDAg.
INTERACTION: P19525:EIF2AK2; NbExp=2; IntAct=EBI-1055820, EBI-640775;
SUBCELLULAR LOCATION: Cytoplasm, P-body.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
SEQUENCE CAUTION: Sequence=BAB13457.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAB85000.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.69 RPKM in Testis
Total median expression: 559.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.70136-0.321 Picture PostScript Text
3' UTR -68.00232-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026122 - MOV-10/Armitage

Pfam Domains:
PF04851 - Type III restriction enzyme, res subunit
PF13086 - AAA domain
PF13087 - AAA domain
PF13245 - AAA domain
PF13604 - AAA domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9HCE1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0031047 gene silencing by RNA
GO:0035195 gene silencing by miRNA
GO:0035279 mRNA cleavage involved in gene silencing by miRNA
GO:0045652 regulation of megakaryocyte differentiation

Cellular Component:
GO:0000932 P-body
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AL833353 - Homo sapiens mRNA; cDNA DKFZp686L0635 (from clone DKFZp686L0635).
LF383824 - JP 2014500723-A/191327: Polycomb-Associated Non-Coding RNAs.
AK310512 - Homo sapiens cDNA, FLJ17554.
AK226011 - Homo sapiens mRNA for Mov10, Moloney leukemia virus 10, homolog, clone: FCC107H12.
LF352929 - JP 2014500723-A/160432: Polycomb-Associated Non-Coding RNAs.
AK023297 - Homo sapiens cDNA FLJ13235 fis, clone OVARC1000304, highly similar to PROTEIN MOV-10.
AB046851 - Homo sapiens KIAA1631 mRNA for KIAA1631 protein.
BX647787 - Homo sapiens mRNA; cDNA DKFZp686I1486 (from clone DKFZp686I1486).
BC009312 - Homo sapiens Mov10, Moloney leukemia virus 10, homolog (mouse), mRNA (cDNA clone MGC:15000 IMAGE:4109453), complete cds.
BC025339 - Homo sapiens Mov10, Moloney leukemia virus 10, homolog (mouse), mRNA (cDNA clone IMAGE:4900792).
AK074174 - Homo sapiens mRNA for FLJ00247 protein.
BC002548 - Homo sapiens Mov10, Moloney leukemia virus 10, homolog (mouse), mRNA (cDNA clone MGC:2948 IMAGE:3138543), complete cds.
JD516084 - Sequence 497108 from Patent EP1572962.
JD055585 - Sequence 36609 from Patent EP1572962.
JD278123 - Sequence 259147 from Patent EP1572962.
AB527365 - Synthetic construct DNA, clone: pF1KE0313, Homo sapiens MOV10 gene for Mov10, Moloney leukemia virus 10, homolog, without stop codon, in Flexi system.
CU679295 - Synthetic construct Homo sapiens gateway clone IMAGE:100020569 5' read MOV10 mRNA.
AM393007 - Synthetic construct Homo sapiens clone IMAGE:100002283 for hypothetical protein (MOV10 gene).
AM393678 - Synthetic construct Homo sapiens clone IMAGE:100002284 for hypothetical protein (MOV10 gene).
DQ892188 - Synthetic construct clone IMAGE:100004818; FLH183860.01X; RZPDo839H05142D Mov10, Moloney leukemia virus 10, homolog (mouse) (MOV10) gene, encodes complete protein.
DQ896845 - Synthetic construct Homo sapiens clone IMAGE:100011305; FLH183856.01L; RZPDo839H05141D Mov10, Moloney leukemia virus 10, homolog (mouse) (MOV10) gene, encodes complete protein.
KJ891636 - Synthetic construct Homo sapiens clone ccsbBroadEn_01030 MOV10 gene, encodes complete protein.
AK308874 - Homo sapiens cDNA, FLJ98915.
LF352927 - JP 2014500723-A/160430: Polycomb-Associated Non-Coding RNAs.
AK301229 - Homo sapiens cDNA FLJ54557 complete cds, highly similar to helicase MOV-10 (EC 3.6.1.-).
LF352918 - JP 2014500723-A/160421: Polycomb-Associated Non-Coding RNAs.
LF352917 - JP 2014500723-A/160420: Polycomb-Associated Non-Coding RNAs.
BC004499 - Homo sapiens Mov10, Moloney leukemia virus 10, homolog (mouse), mRNA (cDNA clone IMAGE:3832816), partial cds.
AK057353 - Homo sapiens cDNA FLJ32791 fis, clone TESTI2002365, highly similar to helicase MOV-10 (EC 3.6.1.-).
AL832805 - Homo sapiens mRNA; cDNA DKFZp667O1423 (from clone DKFZp667O1423).
LF352911 - JP 2014500723-A/160414: Polycomb-Associated Non-Coding RNAs.
LF352910 - JP 2014500723-A/160413: Polycomb-Associated Non-Coding RNAs.
JD334646 - Sequence 315670 from Patent EP1572962.
JD338300 - Sequence 319324 from Patent EP1572962.
JD420335 - Sequence 401359 from Patent EP1572962.
JD390448 - Sequence 371472 from Patent EP1572962.
LF352908 - JP 2014500723-A/160411: Polycomb-Associated Non-Coding RNAs.
JD343377 - Sequence 324401 from Patent EP1572962.
MA619401 - JP 2018138019-A/191327: Polycomb-Associated Non-Coding RNAs.
MA588506 - JP 2018138019-A/160432: Polycomb-Associated Non-Coding RNAs.
MA588504 - JP 2018138019-A/160430: Polycomb-Associated Non-Coding RNAs.
MA588495 - JP 2018138019-A/160421: Polycomb-Associated Non-Coding RNAs.
MA588494 - JP 2018138019-A/160420: Polycomb-Associated Non-Coding RNAs.
MA588488 - JP 2018138019-A/160414: Polycomb-Associated Non-Coding RNAs.
MA588487 - JP 2018138019-A/160413: Polycomb-Associated Non-Coding RNAs.
MA588485 - JP 2018138019-A/160411: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9HCE1 (Reactome details) participates in the following event(s):

R-HSA-3209151 miR-24 binds p16-INK4a and p14-ARF mRNAs
R-HSA-8935766 miR-378 binds RUNX1 mRNA
R-HSA-8937134 miR-27a binds RUNX1 mRNA
R-HSA-8938440 miR-17 binds RUNX1 mRNA
R-HSA-8938487 miR-20a binds RUNX1 mRNA
R-HSA-8938507 miR-106a binds RUNX1 mRNA
R-HSA-8944650 miR-214 microRNA binds PTEN mRNA
R-HSA-8944706 miR-21 nonendonucleolytic RISC binds PTEN mRNA
R-HSA-1606561 MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
R-HSA-1606682 MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
R-HSA-1912367 MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
R-HSA-1912366 MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
R-HSA-1912363 MIR200B/C microRNAs bind NOTCH1 mRNA
R-HSA-1912368 MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
R-HSA-1912364 MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
R-HSA-1912362 MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
R-HSA-2318752 miR-26A microRNAs bind PTEN mRNA
R-HSA-8935864 miR-302b binds RUNX1 mRNA
R-HSA-8935930 miR-18a binds RUNX1 mRNA
R-HSA-8936058 miR-675 binds RUNX1 mRNA
R-HSA-8944483 miR-17 microRNA binds PTEN mRNA
R-HSA-8948582 miR-17 microRNA binds VAPA mRNA
R-HSA-8948583 miR-17 microRNA binds CNOT6L mRNA
R-HSA-8939129 miR-215 binds RUNX1 mRNA
R-HSA-8948524 PTENP1 mRNA binds miR-19b RISC
R-HSA-8948569 miR-19b microRNA binds PTEN mRNA
R-HSA-8948612 miR-19b microRNA binds CNOT6L mRNA
R-HSA-8944538 miR-22 microRNA binds PTEN mRNA
R-HSA-8944569 miR-25 microRNA binds PTEN mRNA
R-HSA-8944599 miR-93 microRNA binds PTEN mRNA
R-HSA-8944632 miR-106 microRNAs bind PTEN mRNA
R-HSA-8948641 miR-106 microRNAs bind VAPA mRNA
R-HSA-8948651 miR-106a,(miR106b) microRNA binds CNOT6L mRNA
R-HSA-8944684 miR-205 microRNA binds PTEN mRNA
R-HSA-8945709 miR-20 microRNAs bind PTEN mRNA
R-HSA-8948536 PTENP1 mRNA binds miR-20 RISC
R-HSA-8948621 miR-20 microRNAs bind VAPA mRNA
R-HSA-8948623 miR-20 microRNAs bind CNOT6L mRNA
R-HSA-8944522 miR-19a microRNA binds PTEN mRNA
R-HSA-8948594 miR-19a microRNA binds VAPA mRNA
R-HSA-8948602 miR-19a microRNA binds CNOT6L mRNA
R-HSA-9011958 miR-26A and B bind to the 3'UTR of the GREB1 mRNA
R-HSA-9012203 miR-26A and B bind to the 3'UTR of the CHD11 mRNA
R-HSA-9012208 miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8943723 Regulation of PTEN mRNA translation
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-2559583 Cellular Senescence
R-HSA-4086398 Ca2+ pathway
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation
R-HSA-6807070 PTEN Regulation
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-2262752 Cellular responses to stress
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-212436 Generic Transcription Pathway
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-157118 Signaling by NOTCH
R-HSA-8939211 ESR-mediated signaling
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-195721 Signaling by WNT
R-HSA-162582 Signal Transduction
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000369645.1, ENST00000369645.2, ENST00000369645.3, ENST00000369645.4, ENST00000369645.5, KIAA1631, MOV10 , MOV10_HUMAN, NM_001321324, Q5JR03, Q8TEF0, Q9BSY3, Q9BUJ9, Q9HCE1, uc318hsv.1, uc318hsv.2
UCSC ID: ENST00000369645.6_3
RefSeq Accession: NM_001321324.2
Protein: Q9HCE1 (aka MOV10_HUMAN or MV10_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.