Human Gene MPHOSPH10 (ENST00000244230.7_5) from GENCODE V47lift37
  Description: M-phase phosphoprotein 10 (from RefSeq NM_005791.3)
Gencode Transcript: ENST00000244230.7_5
Gencode Gene: ENSG00000124383.11_9
Transcript (Including UTRs)
   Position: hg19 chr2:71,357,764-71,377,231 Size: 19,468 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr2:71,357,796-71,377,145 Size: 19,350 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:71,357,764-71,377,231)mRNA (may differ from genome)Protein (681 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MPP10_HUMAN
DESCRIPTION: RecName: Full=U3 small nucleolar ribonucleoprotein protein MPP10; AltName: Full=M phase phosphoprotein 10;
FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with IMP3 and IMP4.
SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome. Note=Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with nucleolus is preceeded by the arrival of fibrillarin.
PTM: Phosphorylated in M (mitotic) phase.
SIMILARITY: Belongs to the MPP10 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.62 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 474.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3032-0.228 Picture PostScript Text
3' UTR -9.8086-0.114 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007151 - Mpp10
IPR012173 - snoRNP_Mpp10

Pfam Domains:
PF04006 - Mpp10 protein

ModBase Predicted Comparative 3D Structure on O00566
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0000375 RNA splicing, via transesterification reactions
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0008380 RNA splicing
GO:0010923 negative regulation of phosphatase activity
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0032040 small-subunit processome
GO:0034457 Mpp10 complex


-  Descriptions from all associated GenBank mRNAs
  AK056862 - Homo sapiens cDNA FLJ32300 fis, clone PROST2002227, highly similar to U3 small nucleolar ribonucleoprotein protein MPP10.
BC126389 - Homo sapiens M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein), mRNA (cDNA clone MGC:161667 IMAGE:8992105), complete cds.
AK310931 - Homo sapiens cDNA, FLJ17973.
BC041084 - Homo sapiens M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein), mRNA (cDNA clone IMAGE:4997590).
X98494 - H.sapiens mRNA for M phase phosphoprotein 10.
BC015158 - Homo sapiens M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein), mRNA (cDNA clone IMAGE:3885617), partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O00566 (Reactome details) participates in the following event(s):

R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVJ8, ENST00000244230.1, ENST00000244230.2, ENST00000244230.3, ENST00000244230.4, ENST00000244230.5, ENST00000244230.6, MPHOSPH10 , MPP10, MPP10_HUMAN, NM_005791, O00566, uc317eod.1, uc317eod.2
UCSC ID: ENST00000244230.7_5
RefSeq Accession: NM_005791.3
Protein: O00566 (aka MPP10_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.