Human Gene MPHOSPH9 (ENST00000606320.6_12) from GENCODE V47lift37
  Description: M-phase phosphoprotein 9, transcript variant 1 (from RefSeq NM_022782.4)
Gencode Transcript: ENST00000606320.6_12
Gencode Gene: ENSG00000051825.15_18
Transcript (Including UTRs)
   Position: hg19 chr12:123,638,762-123,717,688 Size: 78,927 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr12:123,641,354-123,714,911 Size: 73,558 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:123,638,762-123,717,688)mRNA (may differ from genome)Protein (1183 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MPP9_HUMAN
DESCRIPTION: RecName: Full=M-phase phosphoprotein 9;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein (Probable). Note=Localizes to the distal and proximal end of centriole pairs in duplicated centrosomes. In ciliated cells, localizes to the distal and proximal end of daughter centriole and proximal of the mother centriole but not in the distal end of the mother centriole.
PTM: Phosphorylated in M (mitotic) phase.
SEQUENCE CAUTION: Sequence=BAB14359.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.44 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 97.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -51.90225-0.231 Picture PostScript Text
3' UTR -681.002592-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026636 - MPHOSPH9

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q99550
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005814 centriole
GO:0005856 cytoskeleton
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  X98258 - H.sapiens mRNA for M-phase phosphoprotein, mpp9.
BC032906 - Homo sapiens cDNA clone IMAGE:5264009.
BC036600 - Homo sapiens cDNA clone IMAGE:5274123.
LF384021 - JP 2014500723-A/191524: Polycomb-Associated Non-Coding RNAs.
AK023016 - Homo sapiens cDNA FLJ12954 fis, clone NT2RP2005491, weakly similar to PARAMYOSIN.
AK091181 - Homo sapiens cDNA FLJ33862 fis, clone CTONG2006377, highly similar to Homo sapiens M-phase phosphoprotein 9 (MPHOSPH9), mRNA.
AX746832 - Sequence 357 from Patent EP1308459.
AK096541 - Homo sapiens cDNA FLJ39222 fis, clone OCBBF2007121, highly similar to M-PHASE PHOSPHOPROTEIN 9.
BC130440 - Homo sapiens M-phase phosphoprotein 9, mRNA (cDNA clone MGC:163312 IMAGE:40146471), complete cds.
BC144016 - Homo sapiens cDNA clone IMAGE:9052536.
BC144017 - Homo sapiens cDNA clone IMAGE:9052537.
LF359668 - JP 2014500723-A/167171: Polycomb-Associated Non-Coding RNAs.
JD504516 - Sequence 485540 from Patent EP1572962.
JD295496 - Sequence 276520 from Patent EP1572962.
KJ892955 - Synthetic construct Homo sapiens clone ccsbBroadEn_02349 MPHOSPH9 gene, encodes complete protein.
JD409992 - Sequence 391016 from Patent EP1572962.
AL096751 - Homo sapiens mRNA; cDNA DKFZp434J034 (from clone DKFZp434J034).
JD540755 - Sequence 521779 from Patent EP1572962.
JD164687 - Sequence 145711 from Patent EP1572962.
JD040323 - Sequence 21347 from Patent EP1572962.
JD046455 - Sequence 27479 from Patent EP1572962.
JD042443 - Sequence 23467 from Patent EP1572962.
LF359670 - JP 2014500723-A/167173: Polycomb-Associated Non-Coding RNAs.
LF359676 - JP 2014500723-A/167179: Polycomb-Associated Non-Coding RNAs.
LF359677 - JP 2014500723-A/167180: Polycomb-Associated Non-Coding RNAs.
JD087408 - Sequence 68432 from Patent EP1572962.
JD321652 - Sequence 302676 from Patent EP1572962.
JD423394 - Sequence 404418 from Patent EP1572962.
LF359679 - JP 2014500723-A/167182: Polycomb-Associated Non-Coding RNAs.
LF359682 - JP 2014500723-A/167185: Polycomb-Associated Non-Coding RNAs.
LF359683 - JP 2014500723-A/167186: Polycomb-Associated Non-Coding RNAs.
LF359684 - JP 2014500723-A/167187: Polycomb-Associated Non-Coding RNAs.
MA619598 - JP 2018138019-A/191524: Polycomb-Associated Non-Coding RNAs.
MA595245 - JP 2018138019-A/167171: Polycomb-Associated Non-Coding RNAs.
MA595247 - JP 2018138019-A/167173: Polycomb-Associated Non-Coding RNAs.
MA595253 - JP 2018138019-A/167179: Polycomb-Associated Non-Coding RNAs.
MA595254 - JP 2018138019-A/167180: Polycomb-Associated Non-Coding RNAs.
MA595256 - JP 2018138019-A/167182: Polycomb-Associated Non-Coding RNAs.
MA595259 - JP 2018138019-A/167185: Polycomb-Associated Non-Coding RNAs.
MA595260 - JP 2018138019-A/167186: Polycomb-Associated Non-Coding RNAs.
MA595261 - JP 2018138019-A/167187: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MTP3, A1L486, A6NEE2, B3KR87, ENST00000606320.1, ENST00000606320.2, ENST00000606320.3, ENST00000606320.4, ENST00000606320.5, MPP9, MPP9_HUMAN, NM_022782, Q99550, Q9H976, U3KQ28, uc327jqq.1, uc327jqq.2
UCSC ID: ENST00000606320.6_12
RefSeq Accession: NM_022782.4
Protein: Q99550 (aka MPP9_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.