ID:MPI_HUMAN DESCRIPTION: RecName: Full=Mannose-6-phosphate isomerase; EC=5.3.1.8; AltName: Full=Phosphohexomutase; AltName: Full=Phosphomannose isomerase; Short=PMI; FUNCTION: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. CATALYTIC ACTIVITY: D-mannose 6-phosphate = D-fructose 6- phosphate. COFACTOR: Binds 1 zinc ion per subunit (By similarity). PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6- phosphate: step 1/2. SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Expressed in all tissues, but more abundant in heart, brain and skeletal muscle. DISEASE: Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under- glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy. SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 1 family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MPI";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P34949
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000032 cell wall mannoprotein biosynthetic process GO:0005975 carbohydrate metabolic process GO:0006486 protein glycosylation GO:0009298 GDP-mannose biosynthetic process GO:0061611 mannose to fructose-6-phosphate metabolic process
BioCarta from NCI Cancer Genome Anatomy Project h_pepiPathway - Proepithelin Conversion to Epithelin and Wound Repair Control
Reactome (by CSHL, EBI, and GO)
Protein P34949 (Reactome details) participates in the following event(s):
R-HSA-532549 MPI isomerises Fru6P to Man6P R-HSA-446205 Synthesis of GDP-mannose R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
