ID:EM55_HUMAN DESCRIPTION: RecName: Full=55 kDa erythrocyte membrane protein; Short=p55; AltName: Full=Membrane protein, palmitoylated 1; FUNCTION: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). SUBUNIT: Heterodimer with MPP5. Interacts with DLG5 and NF2. Interacts (via guanylate kinase-like domain) with WHRN (via third PDZ domain). INTERACTION: Q96CV9:OPTN; NbExp=2; IntAct=EBI-711788, EBI-748974; SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Cell projection, stereocilium (By similarity). Note=Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity). Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non- myelin-forming Schwann cells. TISSUE SPECIFICITY: Ubiquitous. PTM: Extensively palmitoylated by ZDHHC17, palmitoylation is essential for membrane organization and is crucial for proper erythrocytes morphology. SIMILARITY: Belongs to the MAGUK family. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q00013
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004385 guanylate kinase activity GO:0005515 protein binding
Biological Process: GO:0007165 signal transduction GO:0046037 GMP metabolic process GO:0046710 GDP metabolic process GO:0090022 regulation of neutrophil chemotaxis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
