ID:THTM_HUMAN DESCRIPTION: RecName: Full=3-mercaptopyruvate sulfurtransferase; Short=MST; EC=2.8.1.2; FUNCTION: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis. CATALYTIC ACTIVITY: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. SUBUNIT: Monomer or disulfide-linked homodimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm. DOMAIN: The structure consists of 2 domains of very similar conformation, suggesting a common evolutionary origin. However, the sequences of the 2 domains are very different. SIMILARITY: Contains 2 rhodanese domains. CAUTION: Was originally (PubMed:1953758) thought to be rhodanese.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25325
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P25325 (Reactome details) participates in the following event(s):
R-HSA-9034756 MPST transfers sulfur atom from 3MPYR to form CysS248-MPST R-HSA-9035484 CysS248-MPST:TXN2 dissociates R-HSA-9035227 TXN2 binds CysS248-MPST R-HSA-9012721 MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR R-HSA-9013471 MPST transfers sulfur from 3MPYR to HCN to form HSCN R-HSA-9013533 MPST transfers sulfur from sulfanegen to HCN to form HSCN R-HSA-1614558 Degradation of cysteine and homocysteine R-HSA-1614635 Sulfur amino acid metabolism R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1430728 Metabolism
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
