Human Gene MRAS (ENST00000423968.7_4) from GENCODE V47lift37
  Description: muscle RAS oncogene homolog, transcript variant 2 (from RefSeq NM_001085049.3)
Gencode Transcript: ENST00000423968.7_4
Gencode Gene: ENSG00000158186.13_10
Transcript (Including UTRs)
   Position: hg19 chr3:138,067,421-138,124,375 Size: 56,955 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr3:138,091,726-138,121,111 Size: 29,386 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:138,067,421-138,124,375)mRNA (may differ from genome)Protein (208 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MRAS
Diseases sorted by gene-association score: vertebral artery occlusion (8), causalgia (7), vertebrobasilar insufficiency (6), cerebral arterial disease (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.81 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 775.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.40207-0.567 Picture PostScript Text
3' UTR -1064.003264-0.326 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR020849 - Small_GTPase_Ras

Pfam Domains:
PF00009 - Elongation factor Tu GTP binding domain
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q6FGP0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005525 GTP binding

Biological Process:
GO:0007165 signal transduction
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK124954 - Homo sapiens cDNA FLJ42964 fis, clone BRSTN2013741, highly similar to Ras-related protein M-Ras.
AK316071 - Homo sapiens cDNA, FLJ78970 complete cds, highly similar to Ras-related protein M-Ras.
BC047690 - Homo sapiens muscle RAS oncogene homolog, mRNA (cDNA clone IMAGE:5748709).
AF043938 - Homo sapiens Ras-related protein M-Ras/R-Ras3 mRNA, complete cds.
JD521253 - Sequence 502277 from Patent EP1572962.
AK295640 - Homo sapiens cDNA FLJ50163 complete cds, highly similar to Ras-related protein M-Ras.
BC035939 - Homo sapiens muscle RAS oncogene homolog, mRNA (cDNA clone IMAGE:4814537).
JD052853 - Sequence 33877 from Patent EP1572962.
AB528810 - Synthetic construct DNA, clone: pF1KE0279, Homo sapiens MRAS gene for muscle RAS oncogene homolog, without stop codon, in Flexi system.
BC156845 - Synthetic construct Homo sapiens clone IMAGE:100062541, MGC:190551 muscle RAS oncogene homolog (MRAS) mRNA, encodes complete protein.
CR542067 - Homo sapiens full open reading frame cDNA clone RZPDo834E0636D for gene MRAS, muscle RAS oncogene homolog; complete cds, without stopcodon.
BT020057 - Homo sapiens muscle RAS oncogene homolog mRNA, complete cds.
AF022080 - Homo sapiens R-ras3 mRNA, complete cds.
AF493918 - Homo sapiens Ras family small GTP binding protein M-Ras (MRAS) mRNA, complete cds.
KJ902234 - Synthetic construct Homo sapiens clone ccsbBroadEn_11628 MRAS gene, encodes complete protein.
JD192467 - Sequence 173491 from Patent EP1572962.
AK123833 - Homo sapiens cDNA FLJ41839 fis, clone NT2RI3001981.
JD044338 - Sequence 25362 from Patent EP1572962.
JD073917 - Sequence 54941 from Patent EP1572962.
AK056337 - Homo sapiens cDNA FLJ31775 fis, clone NT2RI2008115.
AK091633 - Homo sapiens cDNA FLJ34314 fis, clone FEBRA2008302.
BC047101 - Homo sapiens muscle RAS oncogene homolog, mRNA (cDNA clone IMAGE:5311267).
BC017733 - Homo sapiens, clone IMAGE:4150216, mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DNE8, ENST00000423968.1, ENST00000423968.2, ENST00000423968.3, ENST00000423968.4, ENST00000423968.5, ENST00000423968.6, hCG_17104 , MRAS , NM_001085049, Q6FGP0, Q6FGP0_HUMAN, uc319tfz.1, uc319tfz.2
UCSC ID: ENST00000423968.7_4
RefSeq Accession: NM_001085049.3
Protein: Q6FGP0

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene MRAS:
noonan (Noonan Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.