Human Gene MRPS28 (ENST00000276585.9_7) from GENCODE V47lift37

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Description: mitochondrial ribosomal protein S28 (from RefSeq NM_014018.3)
Gencode Transcript: ENST00000276585.9_7
Gencode Gene: ENSG00000147586.10_13
Transcript (Including UTRs)
Position: hg19 chr8:80,830,952-80,942,494 Size: 111,543 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr8:80,831,215-80,942,483 Size: 111,269 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:80,830,952-80,942,494)			mRNA (may differ from genome)		Protein (187 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RT28_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S28, mitochondrial; Short=MRP-S28; Short=S28mt; AltName: Full=28S ribosomal protein S35, mitochondrial; Short=MRP-S35; Short=S35mt; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. SUBCELLULAR LOCATION: Mitochondrion.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C016403 2,4-dinitrotoluene C009505 4,4'-diaminodiphenylmethane D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D002251 Carbon Tetrachloride D002945 Cisplatin D002994 Clofibrate D004391 Dust C568376 MT19c compound D011374 Progesterone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 28.73 RPKM in Adrenal Gland Total median expression: 578.45 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-50.40	263	-0.192	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR019375 - Ribosomal_S28_mit
IPR022967 - RNA-binding_domain_S1

Pfam Domains:
PF10246 - Mitochondrial ribosomal protein MRP-S35

SCOP Domains:
50249 - Nucleic acid-binding proteins

ModBase Predicted Comparative 3D Structure on Q9Y2Q9


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding Biological Process: GO:0008150 biological_process GO:0070125 mitochondrial translational elongation GO:0070126 mitochondrial translational termination Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005763 mitochondrial small ribosomal subunit GO:0005840 ribosome

Descriptions from all associated GenBank mRNAs


	AF070663 - Homo sapiens HSPC007 mRNA, complete cds. AK026506 - Homo sapiens cDNA: FLJ22853 fis, clone KAT00869, highly similar to AF070663 Homo sapiens HSPC007 mRNA. AK223069 - Homo sapiens mRNA for mitochondrial ribosomal protein S28 variant, clone: KAT00869. BC010150 - Homo sapiens mitochondrial ribosomal protein S28, mRNA (cDNA clone MGC:19500 IMAGE:4331173), complete cds. EF152584 - Homo sapiens PC1/MRPS28 fusion protein mRNA, complete cds. AK315739 - Homo sapiens cDNA, FLJ96848, Homo sapiens mitochondrial ribosomal protein S28 (MRPS28), nucleargene encoding mitochondrial protein, mRNA. JF432581 - Synthetic construct Homo sapiens clone IMAGE:100073817 mitochondrial ribosomal protein S28 (MRPS28) gene, encodes complete protein. KU178612 - Homo sapiens mitochondrial ribosomal protein S28 isoform 1 (MRPS28) mRNA, partial cds; nuclear gene for mitochondrial product. KU178613 - Homo sapiens mitochondrial ribosomal protein S28 isoform 2 (MRPS28) mRNA, partial cds, alternatively spliced; nuclear gene for mitochondrial product. KU178614 - Homo sapiens mitochondrial ribosomal protein S28 isoform 4 (MRPS28) mRNA, partial cds, alternatively spliced; nuclear gene for mitochondrial product.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9Y2Q9 (Reactome details) participates in the following event(s): R-HSA-5368279 MTIF3 binds 28S ribosomal subunit R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: B2RDZ7, ENST00000276585.1, ENST00000276585.2, ENST00000276585.3, ENST00000276585.4, ENST00000276585.5, ENST00000276585.6, ENST00000276585.7, ENST00000276585.8, HSPC007, MRPS35, NM_014018, Q96Q21, Q9Y2Q9, RT28_HUMAN, uc317jkx.1, uc317jkx.2 UCSC ID: ENST00000276585.9_7 RefSeq Accession: NM_014018.3 Protein: Q9Y2Q9 (aka RT28_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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