Human Gene KGD4 (ENST00000256441.5_4) from GENCODE V47lift37
  Description: mitochondrial ribosomal protein S36 (from RefSeq NM_033281.6)
Gencode Transcript: ENST00000256441.5_4
Gencode Gene: ENSG00000134056.12_8
Transcript (Including UTRs)
   Position: hg19 chr5:68,513,587-68,525,985 Size: 12,399 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr5:68,513,657-68,525,052 Size: 11,396 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:68,513,587-68,525,985)mRNA (may differ from genome)Protein (103 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIOMIM
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RT36_HUMAN
DESCRIPTION: RecName: Full=28S ribosomal protein S36, mitochondrial; Short=MRP-S36; Short=S36mt;
SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
SUBCELLULAR LOCATION: Mitochondrion.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.68 RPKM in Heart - Left Ventricle
Total median expression: 593.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.0070-0.371 Picture PostScript Text
3' UTR -183.60933-0.197 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on P82909
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation
GO:0070125 mitochondrial translational elongation
GO:0070126 mitochondrial translational termination

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0009353 mitochondrial oxoglutarate dehydrogenase complex


-  Descriptions from all associated GenBank mRNAs
  BC015966 - Homo sapiens mitochondrial ribosomal protein S36, mRNA (cDNA clone MGC:22896 IMAGE:4068931), complete cds.
JD270875 - Sequence 251899 from Patent EP1572962.
BC017900 - Homo sapiens mitochondrial ribosomal protein S36, mRNA (cDNA clone MGC:23805 IMAGE:4251462), complete cds.
JD409026 - Sequence 390050 from Patent EP1572962.
HQ448669 - Synthetic construct Homo sapiens clone IMAGE:100072110; CCSB007559_01 mitochondrial ribosomal protein S36 (MRPS36) gene, encodes complete protein.
KJ895179 - Synthetic construct Homo sapiens clone ccsbBroadEn_04573 MRPS36 gene, encodes complete protein.
AF271777 - Homo sapiens DC47 mRNA, complete cds.
LF369376 - JP 2014500723-A/176879: Polycomb-Associated Non-Coding RNAs.
AF086034 - Homo sapiens full length insert cDNA clone YW26F06.
LF369375 - JP 2014500723-A/176878: Polycomb-Associated Non-Coding RNAs.
JD355048 - Sequence 336072 from Patent EP1572962.
JD491450 - Sequence 472474 from Patent EP1572962.
JD512356 - Sequence 493380 from Patent EP1572962.
MA604953 - JP 2018138019-A/176879: Polycomb-Associated Non-Coding RNAs.
MA604952 - JP 2018138019-A/176878: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P82909 (Reactome details) participates in the following event(s):

R-HSA-5368279 MTIF3 binds 28S ribosomal subunit
R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA
R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA
R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation)
R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5419276 Mitochondrial translation termination
R-HSA-5368287 Mitochondrial translation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: DC47, ENST00000256441.1, ENST00000256441.2, ENST00000256441.3, ENST00000256441.4, KGD4 , KGD4_HUMAN, MRPS36, NM_033281, P82909, Q9H2H4, uc317fur.1, uc317fur.2
UCSC ID: ENST00000256441.5_4
RefSeq Accession: NM_033281.6
Protein: P82909 (aka RT36_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.