Human Gene MRRF (ENST00000297908.7_1) from GENCODE V47lift37
  Description: mitochondrial ribosome recycling factor, transcript variant 3 (from RefSeq NM_001173512.3)
Gencode Transcript: ENST00000297908.7_1
Gencode Gene: ENSG00000148187.18_9
Transcript (Including UTRs)
   Position: hg19 chr9:125,026,882-125,085,740 Size: 58,859 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr9:125,033,171-125,084,896 Size: 51,726 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:125,026,882-125,085,740)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RRFM_HUMAN
DESCRIPTION: RecName: Full=Ribosome-recycling factor, mitochondrial; Short=RRF; AltName: Full=Ribosome-releasing factor, mitochondrial; Flags: Precursor;
FUNCTION: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SIMILARITY: Belongs to the RRF family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MRRF
Diseases sorted by gene-association score: robinow syndrome, autosomal recessive (9), uremic neuropathy (8), epidemic typhus (8), lipomatosis, multiple symmetric (8), robinow syndrome (7), benign paroxysmal positional nystagmus (7), rocky mountain spotted fever (6), granuloma annulare (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.24 RPKM in Testis
Total median expression: 607.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -156.20364-0.429 Picture PostScript Text
3' UTR -236.20844-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024946 - Arg_repress_C-like
IPR002661 - Ribosome_recyc_fac
IPR023584 - Ribosome_recyc_fac_dom

Pfam Domains:
PF01765 - Ribosome recycling factor

SCOP Domains:
55194 - Ribosome recycling factor, RRF

ModBase Predicted Comparative 3D Structure on Q96E11
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0043023 ribosomal large subunit binding

Biological Process:
GO:0006412 translation
GO:0032790 ribosome disassembly
GO:0070126 mitochondrial translational termination

Cellular Component:
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix


-  Descriptions from all associated GenBank mRNAs
  AK310974 - Homo sapiens cDNA, FLJ18016.
AK291809 - Homo sapiens cDNA FLJ76638 complete cds, highly similar to Homo sapiens mitochondrial ribosome recycling factor (MRRF), transcript variant 3, mRNA.
AK292790 - Homo sapiens cDNA FLJ78550 complete cds, highly similar to Homo sapiens mitochondrial ribosome recycling factor (MRRF), transcript variant 3, mRNA.
AK298046 - Homo sapiens cDNA FLJ51741 complete cds, highly similar to Ribosome recycling factor, mitochondrial precursor.
AK300718 - Homo sapiens cDNA FLJ50230 complete cds, highly similar to Ribosome recycling factor, mitochondrial precursor.
AK316266 - Homo sapiens cDNA, FLJ79165 complete cds, highly similar to Ribosome recycling factor, mitochondrial precursor.
AK291603 - Homo sapiens cDNA FLJ77144 complete cds, highly similar to Homo sapiens mitochondrial ribosome recycling factor (MRRF), transcript variant 1, mRNA.
BC002814 - Homo sapiens mitochondrial ribosome recycling factor, mRNA (cDNA clone IMAGE:3638276), partial cds.
BC053604 - Homo sapiens mitochondrial ribosome recycling factor, mRNA (cDNA clone MGC:61561 IMAGE:6008684), complete cds.
BC013049 - Homo sapiens mitochondrial ribosome recycling factor, mRNA (cDNA clone MGC:17776 IMAGE:3882448), complete cds.
HQ447351 - Synthetic construct Homo sapiens clone IMAGE:100070672; CCSB000677_04 mitochondrial ribosome recycling factor (MRRF) gene, encodes complete protein.
CU680480 - Synthetic construct Homo sapiens gateway clone IMAGE:100018660 5' read MRRF mRNA.
KJ895185 - Synthetic construct Homo sapiens clone ccsbBroadEn_04579 MRRF gene, encodes complete protein.
JD544042 - Sequence 525066 from Patent EP1572962.
DQ585867 - Homo sapiens piRNA piR-52979, complete sequence.
JD106167 - Sequence 87191 from Patent EP1572962.
JD560449 - Sequence 541473 from Patent EP1572962.
JD116331 - Sequence 97355 from Patent EP1572962.
JD537472 - Sequence 518496 from Patent EP1572962.
JD363808 - Sequence 344832 from Patent EP1572962.
JD551268 - Sequence 532292 from Patent EP1572962.
JD401322 - Sequence 382346 from Patent EP1572962.
JD395194 - Sequence 376218 from Patent EP1572962.
JD244281 - Sequence 225305 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96E11 (Reactome details) participates in the following event(s):

R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
R-HSA-5419276 Mitochondrial translation termination
R-HSA-5368287 Mitochondrial translation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6D8, A8K6Z4, B7Z4X5, B7Z6P7, ENST00000297908.1, ENST00000297908.2, ENST00000297908.3, ENST00000297908.4, ENST00000297908.5, ENST00000297908.6, MRRF , NM_001173512, Q5RKT1, Q5T7T0, Q5T7T1, Q5T7T2, Q5T7T3, Q5T7T4, Q5T7T5, Q96E11, RRFM_HUMAN, uc317mch.1
UCSC ID: ENST00000297908.7_1
RefSeq Accession: NM_001173512.3
Protein: Q96E11 (aka RRFM_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.