ID:MSH4_HUMAN DESCRIPTION: RecName: Full=MutS protein homolog 4; Short=hMSH4; FUNCTION: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. SUBUNIT: Heterooligomer of MSH4 and MSH5. TISSUE SPECIFICITY: Testis and ovary specific. SIMILARITY: Belongs to the DNA mismatch repair MutS family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/msh4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00488 - MutS domain V PF05188 - MutS domain II PF05190 - MutS family domain IV PF05192 - MutS domain III
SCOP Domains: 48334 - DNA repair protein MutS, domain III 52540 - P-loop containing nucleoside triphosphate hydrolases 53150 - DNA repair protein MutS, domain II 53795 - PEP carboxykinase-like
ModBase Predicted Comparative 3D Structure on O15457
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
