Human Gene MST1 (ENST00000449682.3_7) from GENCODE V47lift37
  Description: macrophage stimulating 1, transcript variant 2 (from RefSeq NR_146060.2)
Gencode Transcript: ENST00000449682.3_7
Gencode Gene: ENSG00000173531.16_10
Transcript (Including UTRs)
   Position: hg19 chr3:49,721,380-49,726,907 Size: 5,528 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr3:49,721,461-49,726,124 Size: 4,664 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:49,721,380-49,726,907)mRNA (may differ from genome)Protein (725 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: G3XAK1_HUMAN
DESCRIPTION: SubName: Full=Hepatocyte growth factor-like protein beta chain; SubName: Full=Macrophage stimulating 1 (Hepatocyte growth factor-like), isoform CRA_b;
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 1 peptidase S1 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MST1
Diseases sorted by gene-association score: cholangitis, primary sclerosing* (15), familial renal papillary carcinoma (8), sclerosing cholangitis (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 319.42 RPKM in Liver
Total median expression: 697.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -319.90783-0.409 Picture PostScript Text
3' UTR -14.1081-0.174 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024174 - HGF_MST1
IPR000001 - Kringle
IPR013806 - Kringle-like
IPR018056 - Kringle_CS
IPR003014 - PAN-1_domain
IPR003609 - Pan_app
IPR009003 - Pept_cys/ser_Trypsin-like
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00024 - PAN domain
PF00051 - Kringle domain
PF00089 - Trypsin
PF14295 - PAN domain

SCOP Domains:
50494 - Trypsin-like serine proteases
57414 - Hairpin loop containing domain-like
57440 - Kringle-like

ModBase Predicted Comparative 3D Structure on G3XAK1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0019899 enzyme binding

Biological Process:
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0007566 embryo implantation
GO:0010628 positive regulation of gene expression
GO:0010758 regulation of macrophage chemotaxis
GO:0030317 flagellated sperm motility
GO:0030879 mammary gland development
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0046425 regulation of JAK-STAT cascade
GO:0060763 mammary duct terminal end bud growth
GO:0071456 cellular response to hypoxia
GO:1904036 negative regulation of epithelial cell apoptotic process

Cellular Component:
GO:0005737 cytoplasm
GO:0005773 vacuole


-  Descriptions from all associated GenBank mRNAs
  M74178 - Human hepatocyte growth factor-like protein mRNA, complete cds.
AK222893 - Homo sapiens mRNA for macrophage stimulating 1 (hepatocyte growth factor-like) variant, clone: HEP20874.
L11924 - Homo sapiens macrophage-stimulating protein (MST1) mRNA, complete cds.
BC048330 - Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like), mRNA (cDNA clone MGC:51837 IMAGE:5190966), complete cds.
KJ901583 - Synthetic construct Homo sapiens clone ccsbBroadEn_10977 MST1 gene, encodes complete protein.
KR711039 - Synthetic construct Homo sapiens clone CCSBHm_00019368 MST1 (MST1) mRNA, encodes complete protein.
AK298452 - Homo sapiens cDNA FLJ53076 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.
AK298396 - Homo sapiens cDNA FLJ60766 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.
AK309567 - Homo sapiens cDNA, FLJ99608.
AK294324 - Homo sapiens cDNA FLJ56324 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.
AK296192 - Homo sapiens cDNA FLJ53768 complete cds, highly similar to Hepatocyte growth factor-like protein precursor.
DQ578028 - Homo sapiens piRNA piR-46140, complete sequence.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mspPathway - Msp/Ron Receptor Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000449682.1, ENST00000449682.2, G3XAK1, G3XAK1_HUMAN, hCG_2001992 , MST1 , NR_146060, uc320ref.1, uc320ref.2
UCSC ID: ENST00000449682.3_7
RefSeq Accession: NM_020998.4
Protein: G3XAK1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.