ID:MT3_HUMAN DESCRIPTION: RecName: Full=Metallothionein-3; Short=MT-3; AltName: Full=GIFB; Short=GIF; AltName: Full=Growth inhibitory factor; AltName: Full=Metallothionein-III; Short=MT-III; FUNCTION: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. TISSUE SPECIFICITY: Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain. SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mt3/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P25713
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0000060 protein import into nucleus, translocation GO:0001666 response to hypoxia GO:0001934 positive regulation of protein phosphorylation GO:0006112 energy reserve metabolic process GO:0006707 cholesterol catabolic process GO:0006829 zinc II ion transport GO:0006875 cellular metal ion homeostasis GO:0006882 cellular zinc ion homeostasis GO:0006915 apoptotic process GO:0006979 response to oxidative stress GO:0007420 brain development GO:0008283 cell proliferation GO:0010038 response to metal ion GO:0010507 negative regulation of autophagy GO:0010628 positive regulation of gene expression GO:0010940 positive regulation of necrotic cell death GO:0010942 positive regulation of cell death GO:0014002 astrocyte development GO:0016570 histone modification GO:0019430 removal of superoxide radicals GO:0030308 negative regulation of cell growth GO:0030517 negative regulation of axon extension GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0032095 regulation of response to food GO:0032148 activation of protein kinase B activity GO:0033210 leptin-mediated signaling pathway GO:0034599 cellular response to oxidative stress GO:0035690 cellular response to drug GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043066 negative regulation of apoptotic process GO:0043085 positive regulation of catalytic activity GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043491 protein kinase B signaling GO:0043524 negative regulation of neuron apoptotic process GO:0044242 cellular lipid catabolic process GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0050768 negative regulation of neurogenesis GO:0050821 protein stabilization GO:0051354 negative regulation of oxidoreductase activity GO:0055069 zinc ion homeostasis GO:0055073 cadmium ion homeostasis GO:0060049 regulation of protein glycosylation GO:0060547 negative regulation of necrotic cell death GO:0070371 ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071276 cellular response to cadmium ion GO:0071456 cellular response to hypoxia GO:0071732 cellular response to nitric oxide GO:0097214 positive regulation of lysosomal membrane permeability GO:1901215 negative regulation of neuron death GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000296 negative regulation of hydrogen peroxide catabolic process GO:2000376 positive regulation of oxygen metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
