ID:MTA1_HUMAN DESCRIPTION: RecName: Full=Metastasis-associated protein MTA1; FUNCTION: May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER. SUBUNIT: Component of the nucleosome-remodeling and histone- deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR. Binds to CSNK1G2 in the cytoplasm. SUBCELLULAR LOCATION: Isoform Short: Cytoplasm. SUBCELLULAR LOCATION: Isoform Long: Nucleus. TISSUE SPECIFICITY: Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. DEVELOPMENTAL STAGE: Highly expressed in metastatic cells. DOMAIN: Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif). PTM: Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER). SIMILARITY: Contains 1 BAH domain. SIMILARITY: Contains 1 ELM2 domain. SIMILARITY: Contains 1 GATA-type zinc finger. SIMILARITY: Contains 1 SANT domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MTA1ID41443ch14q32.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13330
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006302 double-strand break repair GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007165 signal transduction GO:0010212 response to ionizing radiation GO:0016575 histone deacetylation GO:0032922 circadian regulation of gene expression GO:0040029 regulation of gene expression, epigenetic GO:0043153 entrainment of circadian clock by photoperiod GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045475 locomotor rhythm GO:0048511 rhythmic process GO:1902499 positive regulation of protein autoubiquitination GO:1903507 negative regulation of nucleic acid-templated transcription
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
