ID:MTP_HUMAN DESCRIPTION: RecName: Full=Microsomal triglyceride transfer protein large subunit; Flags: Precursor; FUNCTION: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. SUBUNIT: Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI) (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum. TISSUE SPECIFICITY: Liver and small intestine. Also found in ovary, testis and kidney. INDUCTION: Positively regulated by cholesterol and negatively regulated by insulin. DISEASE: Defects in MTTP are the cause of abetalipoproteinemia (ABL) [MIM:200100]. ABL is an autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration. SIMILARITY: Contains 1 vitellogenin domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55157
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK302602 - Homo sapiens cDNA FLJ51770 complete cds, highly similar to Microsomal triglyceride transfer protein large subunit precursor. AK225328 - Homo sapiens mRNA for Microsomal triglyceride transfer protein large subunit precursor variant, clone: HEP08255. X59657 - H.sapiens RNA for MTP. AK290793 - Homo sapiens cDNA FLJ76050 complete cds, highly similar to Homo sapiens microsomal triglyceride transfer protein (large polypeptide, 88kDa) (MTP), mRNA. BC125110 - Homo sapiens microsomal triglyceride transfer protein, mRNA (cDNA clone MGC:149819 IMAGE:40118807), complete cds. BC125111 - Homo sapiens microsomal triglyceride transfer protein, mRNA (cDNA clone MGC:149820 IMAGE:40118809), complete cds. X75500 - H.sapiens mRNA for microsomal triglyceride transfer protein. X91148 - H.sapiens mRNA for microsomal triglyceride transfer protein. BC062696 - Homo sapiens microsomal triglyceride transfer protein, mRNA (cDNA clone IMAGE:30382125), complete cds. KJ905831 - Synthetic construct Homo sapiens clone ccsbBroadEn_15501 MTTP gene, encodes complete protein. JD294717 - Sequence 275741 from Patent EP1572962. JD206458 - Sequence 187482 from Patent EP1572962. JD457578 - Sequence 438602 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
