Human Gene MUC16 (ENST00000711672.1_3) from GENCODE V47lift37
  Description: mucin 16, cell surface associated (from HGNC MUC16)
Gencode Transcript: ENST00000711672.1_3
Gencode Gene: ENSG00000181143.17_13
Transcript (Including UTRs)
   Position: hg19 chr19:8,959,520-9,121,066 Size: 161,547 Total Exon Count: 88 Strand: -
Coding Region
   Position: hg19 chr19:8,959,608-9,121,032 Size: 161,425 Coding Exon Count: 88 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:8,959,520-9,121,066)mRNA (may differ from genome)Protein (14569 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerGeneCardsHGNCMalacards
MGIPubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MUC16
Diseases sorted by gene-association score: ovarian cancer, somatic (11), pseudo-meigs syndrome (5), endometriosis (5), bronchogenic cyst (3), peritonitis (3), cystadenocarcinoma (3), corpus luteum cyst (3), tuberculous peritonitis (3), atopic keratoconjunctivitis (3), meige syndrome (2), colorectal cancer 1 (2), pericardial mesothelioma (2), ovarian brenner tumor (2), primary peritoneal carcinoma (2), pleural cancer (2), filamentary keratitis (2), female reproductive organ cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.3034-0.185 Picture PostScript Text
3' UTR -33.7088-0.383 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  AF361486 - Homo sapiens mucin 16 (MUC16) mRNA, partial cds.
AF414442 - Homo sapiens ovarian cancer related tumor marker CA125 mRNA, complete cds.
KU844182 - Homo sapiens mucin-16 short isoform (MUC16) mRNA, complete cds.
KU844183 - Homo sapiens mucin-16 long isoform (MUC16) mRNA, complete cds.
AK128856 - Homo sapiens cDNA FLJ46656 fis, clone TRACH3005699, highly similar to Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.
AK128857 - Homo sapiens cDNA FLJ46662 fis, clone TRACH3006800, highly similar to Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.
AK128681 - Homo sapiens cDNA FLJ46845 fis, clone UTERU3001946, highly similar to Homo sapiens mucin 16 (MUC16).
AK024365 - Homo sapiens cDNA FLJ14303 fis, clone PLACE2000132.
JD166842 - Sequence 147866 from Patent EP1572962.
JD230743 - Sequence 211767 from Patent EP1572962.
JD230689 - Sequence 211713 from Patent EP1572962.
JD459195 - Sequence 440219 from Patent EP1572962.
JD507191 - Sequence 488215 from Patent EP1572962.
AK056791 - Homo sapiens cDNA FLJ32229 fis, clone PLACE6004454, weakly similar to GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3).

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001414686, uc331ogz.1, uc331ogz.2
UCSC ID: ENST00000711672.1_3
Representative RNA: NM_001414686

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.