Human Gene MUC2 (ENST00000675028.1_6) from GENCODE V47lift37
  Description: mucin 2, oligomeric mucus/gel-forming (from HGNC MUC2)
Gencode Transcript: ENST00000675028.1_6
Gencode Gene: ENSG00000198788.9_8
Transcript (Including UTRs)
   Position: hg19 chr11:1,074,875-1,092,363 Size: 17,489 Total Exon Count: 30 Strand: +
Coding Region
   Position: hg19 chr11:1,074,902-1,092,363 Size: 17,462 Coding Exon Count: 30 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:1,074,875-1,092,363)mRNA (may differ from genome)Protein (1394 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCMalacards
MGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MUC2
Diseases sorted by gene-association score: pseudomyxoma peritonei (35), signet ring cell adenocarcinoma (34), biliary tract neoplasm (28), mucinous adenocarcinoma (25), biliary papillomatosis (24), ulcerative colitis (23), gallbladder adenocarcinoma (23), colitis (23), pancreatic mucinous cystadenoma (22), appendix cancer (22), pancreatic ductal carcinoma (20), cystadenocarcinoma (20), gallbladder cancer (19), tubular adenocarcinoma (18), ampulla of vater adenocarcinoma (17), bile duct cystadenocarcinoma (16), gastric tubular adenocarcinoma (15), chronic cholangitis (15), bile duct carcinoma (14), cap polyposis (12), intrahepatic cholangiocarcinoma (12), cholangiocarcinoma, susceptibility to (12), colorectal cancer (11), small intestine cancer (11), chronic ethmoiditis (11), mucinous cystadenocarcinoma (11), mucinous intrahepatic cholangiocarcinoma (11), ovarian mucinous adenocarcinoma (11), colloid carcinoma of the pancreas (10), clear cell adenoma (10), crohn's disease (10), ampulla of vater neoplasm (9), mucoepidermoid carcinoma (9), polyposis, skin pigmentation, alopecia, and fingernail changes (9), bile duct mucoepidermoid carcinoma (8), cystadenoma (8), microinvasive gastric cancer (8), barrett esophagus/esophageal adenocarcinoma (8), bronchiolo-alveolar adenocarcinoma (8), colon mucinous adenocarcinoma (8), pancreatic intraductal papillary-mucinous neoplasm (8), cystic teratoma (8), papillary adenocarcinoma (7), duodenum cancer (7), colorectal cancer 1 (7), colorectal adenocarcinoma (7), gastrointestinal carcinoma (7), tumor of exocrine pancreas (7), meconium ileus (7), ethmoid sinusitis (7), hidradenocarcinoma (7), small intestinal adenocarcinoma (7), pancreatic cancer (6), bile duct adenocarcinoma (6), epstein-barr virus-associated gastric carcinoma (6), eyelid neoplasm (6), mucinous tubular and spindle renal cell carcinoma (6), cholecystitis (6), otitis media (6), gastrointestinal system benign neoplasm (6), superior mesenteric artery syndrome (5), cystitis cystica (5), suppurative cholangitis (5), appendix adenocarcinoma (5), ovarian mucinous neoplasm (5), secretory meningioma (4), stomach cancer (4), adenoma (4), gastric cancer, somatic (4), cystic fibrosis (2), lynch syndrome (2), cell type benign neoplasm (1), cell type cancer (1), gastrointestinal system cancer (1), colonic benign neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00270.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  L21998 - Homo sapiens intestinal mucin (MUC2) mRNA, complete cds.
M94131 - Human mucin 2 (MUC2) mRNA, partial cds.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_tffPathway - Trefoil Factors Initiate Mucosal Healing

-  Other Names for This Gene
  Alternate Gene Symbols: A0A6Q8PGX3, A0A6Q8PGX3_HUMAN, L21998, MUC2 , uc329zdc.1, uc329zdc.2
UCSC ID: ENST00000675028.1_6
Representative RNA: L21998

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.