Human Gene MUC5AC (ENST00000356191.2) from GENCODE V47lift37
  Description: mucin 5AC, oligomeric mucus/gel-forming (from HGNC MUC5AC)
Gencode Transcript: ENST00000356191.2
Gencode Gene: ENSG00000215182.6
Transcript (Including UTRs)
   Position: hg19 chr11:1,151,627-1,162,360 Size: 10,734 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr11:1,151,627-1,162,360 Size: 10,734 Coding Exon Count: 20 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:1,151,627-1,162,360)mRNA (may differ from genome)Protein (620 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCMalacards
MGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MUC5AC
Diseases sorted by gene-association score: pseudomyxoma peritonei (8), pancreatic cancer (7), stomach cancer (6), colorectal cancer (5), mucoepidermoid carcinoma (5), otitis media (5), anal canal adenocarcinoma (5), biliary papillomatosis (4), cystic fibrosis (4), adenoma (4), pancreatic mucinous cystadenoma (4), anal gland adenocarcinoma (3), dry eye syndrome (3), cap polyposis (3), cholangiocarcinoma, susceptibility to (3), intrahepatic cholangiocarcinoma (3), mucinous intrahepatic cholangiocarcinoma (3), breast mucoepidermoid carcinoma (3), barrett esophagus/esophageal adenocarcinoma (3), meconium ileus (2), anus adenocarcinoma (2), atopic keratoconjunctivitis (2), colorectal cancer 1 (2), acinar cell cystadenocarcinoma (2), limbal stem cell deficiency (2), complete androgen insensitivity syndrome (2), asthma (2), epstein-barr virus-associated gastric carcinoma (2), small intestinal adenocarcinoma (2), bile duct mucoepidermoid carcinoma (2), hidradenocarcinoma (2), panophthalmitis (2), polyposis, skin pigmentation, alopecia, and fingernail changes (2), bile duct cystadenocarcinoma (2), chronic ethmoiditis (2), middle ear disease (2), lacrimal apparatus disease (2), bile duct adenocarcinoma (1), pylorospasm (1), clear cell adenoma (1), filamentary keratitis (1), bronchial disease (1), conjunctival nevus (1), respiratory system disease (1), mucinous ovarian cystadenoma (1), gastric cancer, somatic (1), superior mesenteric artery syndrome (1), pancreatic cystadenocarcinoma (1), ethmoid sinusitis (1), conjunctival degeneration (1), listeria meningitis (1), colloid carcinoma of the pancreas (1), gastric tubular adenocarcinoma (1), central nervous system tuberculosis (1), purulent endophthalmitis (1), pinguecula (1), cystitis cystica (1), chronic maxillary sinusitis (1), ovarian mucinous neoplasm (1), critical illness polyneuropathy (1), breast metaplastic carcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 230.92 RPKM in Stomach
Total median expression: 232.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  Protein Domain and Structure Information
  Pfam Domains:
PF00094 - von Willebrand factor type D domain
PF01826 - Trypsin Inhibitor like cysteine rich domain
PF08742 - C8 domain

SCOP Domains:
57567 - Serine protease inhibitors
57603 - FnI-like domain

ModBase Predicted Comparative 3D Structure on Q7LDT3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  AF015521 - Homo sapiens mucin (MUC 5AC) mRNA, partial cds.
AJ298317 - Homo sapiens partial mRNA for mucin 5 (MUC5AC gene).
AF043909 - Homo sapiens gastric mucin (MUC5AC) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AF043909, ENST00000356191.1, MUC 5AC , Q7LDT3, Q7LDT3_HUMAN, uc317zlh.1
UCSC ID: ENST00000356191.2
RefSeq Accession: NM_001304359.2
Protein: Q7LDT3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.