Human Gene MVP (ENST00000357402.10_4) from GENCODE V47lift37
  Description: major vault protein, transcript variant 2 (from RefSeq NM_005115.5)
Gencode Transcript: ENST00000357402.10_4
Gencode Gene: ENSG00000013364.19_10
Transcript (Including UTRs)
   Position: hg19 chr16:29,831,783-29,859,342 Size: 27,560 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr16:29,841,871-29,859,310 Size: 17,440 Coding Exon Count: 14 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:29,831,783-29,859,342)mRNA (may differ from genome)Protein (893 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MVP
Diseases sorted by gene-association score: lung cancer (6), mesial temporal lobe epilepsy with hippocampal sclerosis (5), ovarian cancer, somatic (3), testicular cancer (3), core binding factor acute myeloid leukemia (2), leukemia, acute lymphoblastic (2), uterine sarcoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 110.36 RPKM in Adrenal Gland
Total median expression: 1987.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.4084-0.231 Picture PostScript Text
3' UTR -1.5032-0.047 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  AK026112 - Homo sapiens cDNA: FLJ22459 fis, clone HRC10045.
AK310168 - Homo sapiens cDNA, FLJ17210.
AK301130 - Homo sapiens cDNA FLJ54179 complete cds.
AK298238 - Homo sapiens cDNA FLJ53437 complete cds, highly similar to Major vault protein.
AJ291366 - Homo sapiens partial mRNA for major vault protein (MVP gene), splice variant 1.
AJ291367 - Homo sapiens partial mRNA for major vault protein (MVP gene) and upstream open reading frame (uORF), splice variant 2.
X79882 - Homo sapiens lrp mRNA.
HM005570 - Homo sapiens clone HTL-S-30 testicular secretory protein Li 30 mRNA, complete cds.
AK293302 - Homo sapiens cDNA FLJ54588 complete cds, highly similar to Major vault protein.
AK302052 - Homo sapiens cDNA FLJ53371 complete cds, highly similar to Major vault protein.
BC015623 - Homo sapiens major vault protein, mRNA (cDNA clone MGC:22969 IMAGE:4843712), complete cds.
JD377150 - Sequence 358174 from Patent EP1572962.
JD086928 - Sequence 67952 from Patent EP1572962.
BC008932 - Homo sapiens major vault protein, mRNA (cDNA clone IMAGE:2987946), partial cds.
DQ896352 - Synthetic construct Homo sapiens clone IMAGE:100010812; FLH193546.01L; RZPDo839H0568D major vault protein (MVP) gene, encodes complete protein.
EU176426 - Synthetic construct Homo sapiens clone IMAGE:100006503; FLH193553.01X; RZPDo839G06252D major vault protein (MVP) gene, encodes complete protein.
CU677371 - Synthetic construct Homo sapiens gateway clone IMAGE:100023480 5' read MVP mRNA.
KJ892882 - Synthetic construct Homo sapiens clone ccsbBroadEn_02276 MVP gene, encodes complete protein.
KJ534976 - Homo sapiens clone MVP_iso-F_fetal-F16 major vault protein isoform F (MVP) mRNA, partial cds, alternatively spliced.
KJ534884 - Homo sapiens clone MVP_iso-A_adult-A02 major vault protein isoform A (MVP) mRNA, partial cds, alternatively spliced.
KJ534885 - Homo sapiens clone MVP_iso-C_adult-A04 major vault protein isoform C (MVP) mRNA, partial cds, alternatively spliced.
KJ534886 - Homo sapiens clone MVP_iso-B_fetal-F10 major vault protein isoform B (MVP) mRNA, partial cds, alternatively spliced.
KJ534966 - Homo sapiens clone MVP_iso-H_fetal-F09 major vault protein isoform H (MVP) mRNA, partial cds, alternatively spliced.
KJ534975 - Homo sapiens clone MVP_iso-G_fetal-F11 major vault protein isoform G (MVP) mRNA, partial cds, alternatively spliced.
KJ534990 - Homo sapiens clone MVP_iso-D_adult-A15 major vault protein isoform D (MVP) mRNA, complete cds, alternatively spliced.
KJ535063 - Homo sapiens clone MVP_iso-E_fetal-F01 major vault protein isoform E (MVP) mRNA, complete cds, alternatively spliced.
BC086310 - Homo sapiens cDNA clone IMAGE:6282177, **** WARNING: chimeric clone ****.
JD025756 - Sequence 6780 from Patent EP1572962.
JD033289 - Sequence 14313 from Patent EP1572962.
JD029283 - Sequence 10307 from Patent EP1572962.
JD021289 - Sequence 2313 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000357402.1, ENST00000357402.2, ENST00000357402.3, ENST00000357402.4, ENST00000357402.5, ENST00000357402.6, ENST00000357402.7, ENST00000357402.8, ENST00000357402.9, hCG_1985644 , MVP , NM_005115, uc318aan.1, uc318aan.2, X5D2M8, X5D2M8_HUMAN
UCSC ID: ENST00000357402.10_4
RefSeq Accession: NM_005115.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.