Human Gene MX2 (ENST00000330714.8_4) from GENCODE V47lift37

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Description: MX dynamin like GTPase 2 (from RefSeq NM_002463.2)
Gencode Transcript: ENST00000330714.8_4
Gencode Gene: ENSG00000183486.14_14
Transcript (Including UTRs)
Position: hg19 chr21:42,733,954-42,781,320 Size: 47,367 Total Exon Count: 14 Strand: +
Coding Region
Position: hg19 chr21:42,748,834-42,780,160 Size: 31,327 Coding Exon Count: 13

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr21:42,733,954-42,781,320)			mRNA (may differ from genome)		Protein (715 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: MX2_HUMAN DESCRIPTION: RecName: Full=Interferon-induced GTP-binding protein Mx2; AltName: Full=Interferon-regulated resistance GTP-binding protein MxB; AltName: Full=Myxovirus resistance protein 2; AltName: Full=p78-related protein; SUBCELLULAR LOCATION: Cytoplasm. INDUCTION: By interferons. SIMILARITY: Belongs to the dynamin family. SIMILARITY: Contains 1 GED domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MX2 Diseases sorted by gene-association score: influenza (35), croup (7), narcolepsy (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001564 Benzo(a)pyrene D004958 Estradiol C016403 2,4-dinitrotoluene C027576 4-hydroxy-2-nonenal D000535 Aluminum D000643 Ammonium Chloride D019256 Cadmium Chloride D002251 Carbon Tetrachloride D003314 Corn Oil more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 47.07 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 237.49 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-25.40	100	-0.254	Picture	PostScript	Text
3' UTR	-362.50	1160	-0.312	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR022812 - Dynamin
IPR000375 - Dynamin_central
IPR001401 - Dynamin_GTPase
IPR019762 - Dynamin_GTPase_CS
IPR003130 - GED
IPR020850 - GTPase_effector_domain_GED
IPR015577 - Interferon-induced_Mx

Pfam Domains:
PF00350 - Dynamin family
PF01031 - Dynamin central region
PF02212 - Dynamin GTPase effector domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on P20592


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding GO:0008017 microtubule binding Biological Process: GO:0000266 mitochondrial fission GO:0002376 immune system process GO:0003374 dynamin family protein polymerization involved in mitochondrial fission GO:0006952 defense response GO:0009615 response to virus GO:0015031 protein transport GO:0035455 response to interferon-alpha GO:0045087 innate immune response GO:0046822 regulation of nucleocytoplasmic transport GO:0051028 mRNA transport GO:0051607 defense response to virus GO:0051726 regulation of cell cycle GO:0060337 type I interferon signaling pathway GO:0061025 membrane fusion Cellular Component: GO:0005634 nucleus GO:0005643 nuclear pore GO:0005737 cytoplasm GO:0005829 cytosol GO:0031966 mitochondrial membrane

Descriptions from all associated GenBank mRNAs


	M30818 - Human interferon-induced cellular resistance mediator protein (MxB) mRNA, complete cds. AK308060 - Homo sapiens cDNA, FLJ98008. AK126107 - Homo sapiens cDNA FLJ44119 fis, clone THYMU1000600. AK298780 - Homo sapiens cDNA FLJ58681 complete cds, highly similar to Interferon-induced GTP-binding protein Mx2. BC035293 - Homo sapiens myxovirus (influenza virus) resistance 2 (mouse), mRNA (cDNA clone MGC:34215 IMAGE:5182160), complete cds. JD448389 - Sequence 429413 from Patent EP1572962. JD330532 - Sequence 311556 from Patent EP1572962. JD215571 - Sequence 196595 from Patent EP1572962. DQ892116 - Synthetic construct clone IMAGE:100004746; FLH183175.01X; RZPDo839G09140D myxovirus (influenza virus) resistance 2 (mouse) (MX2) gene, encodes complete protein. DQ895311 - Synthetic construct Homo sapiens clone IMAGE:100009771; FLH183171.01L; RZPDo839G09139D myxovirus (influenza virus) resistance 2 (mouse) (MX2) gene, encodes complete protein. M33883 - Human p78-related protein mRNA, complete cds. AK122952 - Homo sapiens cDNA FLJ16669 fis, clone THYMU3000306, highly similar to INTERFERON-REGULATED RESISTANCE GTP-BINDING PROTEIN MXB. AY312582 - Homo sapiens myxovirus resistance protein 2-like (MX2) mRNA, partial sequence, alternatively spliced. AK124336 - Homo sapiens cDNA FLJ42345 fis, clone UTERU2002473. AK127895 - Homo sapiens cDNA FLJ46001 fis, clone SMINT2011406, highly similar to Interferon-regulated resistance GTP-binding protein MxB. JD202293 - Sequence 183317 from Patent EP1572962. JD188532 - Sequence 169556 from Patent EP1572962. JD379373 - Sequence 360397 from Patent EP1572962. JD371708 - Sequence 352732 from Patent EP1572962. JD343453 - Sequence 324477 from Patent EP1572962. JD226636 - Sequence 207660 from Patent EP1572962. JD109429 - Sequence 90453 from Patent EP1572962. JD226941 - Sequence 207965 from Patent EP1572962. JD196892 - Sequence 177916 from Patent EP1572962. JD359093 - Sequence 340117 from Patent EP1572962. JD402287 - Sequence 383311 from Patent EP1572962. JD093179 - Sequence 74203 from Patent EP1572962. JD549293 - Sequence 530317 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P20592 (Reactome details) participates in the following event(s): R-HSA-1169406 ISGylation of host proteins R-HSA-909733 Interferon alpha/beta signaling R-HSA-1169408 ISG15 antiviral mechanism R-HSA-913531 Interferon Signaling R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: B7Z5D3, D3DSI7, ENST00000330714.1, ENST00000330714.2, ENST00000330714.3, ENST00000330714.4, ENST00000330714.5, ENST00000330714.6, ENST00000330714.7, MX2_HUMAN, NM_002463, P20592, uc317tap.1, uc317tap.2 UCSC ID: ENST00000330714.8_4 RefSeq Accession: NM_002463.2 Protein: P20592 (aka MX2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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