Human Gene MYH13 (ENST00000252172.9_7) from GENCODE V47lift37
  Description: myosin heavy chain 13 (from RefSeq NM_003802.3)
Gencode Transcript: ENST00000252172.9_7
Gencode Gene: ENSG00000006788.14_11
Transcript (Including UTRs)
   Position: hg19 chr17:10,204,182-10,276,323 Size: 72,142 Total Exon Count: 41 Strand: -
Coding Region
   Position: hg19 chr17:10,204,268-10,267,847 Size: 63,580 Coding Exon Count: 39 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:10,204,182-10,276,323)mRNA (may differ from genome)Protein (1938 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MYH13_HUMAN
DESCRIPTION: RecName: Full=Myosin-13; AltName: Full=Myosin heavy chain 13; AltName: Full=Myosin heavy chain, skeletal muscle, extraocular; Short=MyHC-eo;
FUNCTION: Muscle contraction.
SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
DOMAIN: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
SIMILARITY: Contains 1 IQ domain.
SIMILARITY: Contains 1 myosin head-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MYH13
Diseases sorted by gene-association score: tongue disease (9), ankyloglossia (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.11 RPKM in Muscle - Skeletal
Total median expression: 2.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.5091-0.247 Picture PostScript Text
3' UTR -19.5086-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR015650 - Myosin_1/23/4/7/8/13/15
IPR001609 - Myosin_head_motor_dom
IPR004009 - Myosin_N
IPR002928 - Myosin_tail

Pfam Domains:
PF00063 - Myosin head (motor domain)
PF00612 - IQ calmodulin-binding motif
PF01576 - Myosin tail
PF02736 - Myosin N-terminal SH3-like domain

SCOP Domains:
50084 - Myosin S1 fragment, N-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like
90257 - Myosin rod fragments
57997 - Tropomyosin
58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain

ModBase Predicted Comparative 3D Structure on Q9UKX3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000146 microfilament motor activity
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0051015 actin filament binding

Biological Process:
GO:0006936 muscle contraction
GO:0007018 microtubule-based movement
GO:0009267 cellular response to starvation

Cellular Component:
GO:0005737 cytoplasm
GO:0005859 muscle myosin complex
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0032982 myosin filament
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AF111782 - Homo sapiens extraocular muscle myosin heavy chain mRNA, complete cds.
BC156336 - Synthetic construct Homo sapiens clone IMAGE:100061825, MGC:190110 myosin, heavy chain 13, skeletal muscle (MYH13) mRNA, encodes complete protein.
BC157121 - Synthetic construct Homo sapiens clone IMAGE:100063504, MGC:190788 myosin, heavy chain 13, skeletal muscle (MYH13) mRNA, encodes complete protein.
AK294316 - Homo sapiens cDNA FLJ51822 complete cds, highly similar to Myosin-13.
JD437772 - Sequence 418796 from Patent EP1572962.
JD417360 - Sequence 398384 from Patent EP1572962.
JD102619 - Sequence 83643 from Patent EP1572962.
JD436908 - Sequence 417932 from Patent EP1572962.
JD254548 - Sequence 235572 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000252172.1, ENST00000252172.2, ENST00000252172.3, ENST00000252172.4, ENST00000252172.5, ENST00000252172.6, ENST00000252172.7, ENST00000252172.8, MYH13_HUMAN, NM_003802, O95252, Q9P0U8, Q9UKX3, uc317fgh.1, uc317fgh.2
UCSC ID: ENST00000252172.9_7
RefSeq Accession: NM_003802.3
Protein: Q9UKX3 (aka MYH13_HUMAN or MYHD_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.