Human Gene MYO16 (ENST00000457511.7_6) from GENCODE V47lift37
  Description: myosin XVI, transcript variant 1 (from RefSeq NM_001198950.3)
Gencode Transcript: ENST00000457511.7_6
Gencode Gene: ENSG00000041515.16_16
Transcript (Including UTRs)
   Position: hg19 chr13:109,281,959-109,860,353 Size: 578,395 Total Exon Count: 35 Strand: +
Coding Region
   Position: hg19 chr13:109,282,193-109,859,184 Size: 576,992 Coding Exon Count: 35 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:109,281,959-109,860,353)mRNA (may differ from genome)Protein (1880 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F8W883_HUMAN
DESCRIPTION: SubName: Full=Unconventional myosin-XVI;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MYO16
Diseases sorted by gene-association score: schizophrenia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.50 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 17.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.00234-0.286 Picture PostScript Text
3' UTR -313.901169-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR001609 - Myosin_head_motor_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF00063 - Myosin head (motor domain)
PF00612 - IQ calmodulin-binding motif
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)
PF15439 - Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
101447 - Formin homology 2 domain (FH2 domain)
52540 - P-loop containing nucleoside triphosphate hydrolases
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on F8W883
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005524 ATP binding
GO:0044877 macromolecular complex binding

Biological Process:
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0048812 neuron projection morphogenesis

Cellular Component:
GO:0005829 cytosol
GO:0016020 membrane
GO:0016459 myosin complex


-  Descriptions from all associated GenBank mRNAs
  AB020672 - Homo sapiens KIAA0865 mRNA for KIAA0865 protein.
BC146791 - Homo sapiens myosin XVI, mRNA (cDNA clone MGC:166886 IMAGE:9007256), complete cds.
AL834447 - Homo sapiens mRNA; cDNA DKFZp761P189 (from clone DKFZp761P189).
AB290159 - Homo sapiens mRNA for MYO16/KIAA0865 variant protein, complete cds.
AK127806 - Homo sapiens cDNA FLJ45907 fis, clone OCBBF3027969, weakly similar to Homo sapiens myosin IIIA (MYO3A).
AB384024 - Synthetic construct DNA, clone: pF1KSDA0865, Homo sapiens MYO16 gene for myosin-XVI, complete cds, without stop codon, in Flexi system.
KJ905428 - Synthetic construct Homo sapiens clone ccsbBroadEn_15004 MYO16-like gene, encodes complete protein.
AK095691 - Homo sapiens cDNA FLJ38372 fis, clone FEBRA2002410, moderately similar to Rattus norvegicus myosin heavy chain Myr 8 mRNA.
AK302933 - Homo sapiens cDNA FLJ55616 complete cds, highly similar to Homo sapiens myosin heavy chain Myr 8 (MYR8), mRNA.
BC041343 - Homo sapiens cDNA clone IMAGE:5272097.
JD214184 - Sequence 195208 from Patent EP1572962.
JD508525 - Sequence 489549 from Patent EP1572962.
JD450493 - Sequence 431517 from Patent EP1572962.
JD088833 - Sequence 69857 from Patent EP1572962.
JD289378 - Sequence 270402 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000457511.1, ENST00000457511.2, ENST00000457511.3, ENST00000457511.4, ENST00000457511.5, ENST00000457511.6, F8W883, F8W883_HUMAN, MYO16 , NM_001198950, uc320yko.1, uc320yko.2
UCSC ID: ENST00000457511.7_6
RefSeq Accession: NM_001198950.3
Protein: F8W883

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.