Human Gene MYO19 (ENST00000614623.5_7) from GENCODE V47lift37
  Description: myosin XIX, transcript variant 2 (from RefSeq NM_001163735.2)
Gencode Transcript: ENST00000614623.5_7
Gencode Gene: ENSG00000278259.5_12
Transcript (Including UTRs)
   Position: hg19 chr17:34,851,480-34,890,695 Size: 39,216 Total Exon Count: 26 Strand: -
Coding Region
   Position: hg19 chr17:34,852,095-34,888,368 Size: 36,274 Coding Exon Count: 24 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:34,851,480-34,890,695)mRNA (may differ from genome)Protein (970 aa)
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-  Comments and Description Text from UniProtKB
  ID: MYO19_HUMAN
DESCRIPTION: RecName: Full=Unconventional myosin-XIX; AltName: Full=Myosin head domain-containing protein 1;
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. MYO19 is involved in mitochondrial motility.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Mitochondrion outer membrane. Note=Probably associated with the outer membrane via its N-terminal mitochondrial targeting region.
TISSUE SPECIFICITY: Widely expressed in multiple tissues and cell lines.
SIMILARITY: Contains 2 IQ domains.
SIMILARITY: Contains 1 myosin head-like domain.
SEQUENCE CAUTION: Sequence=BAD92272.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -146.60403-0.364 Picture PostScript Text
3' UTR -171.50615-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR001609 - Myosin_head_motor_dom

Pfam Domains:
PF00063 - Myosin head (motor domain)
PF00612 - IQ calmodulin-binding motif

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on Q96H55
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity
GO:0032027 myosin light chain binding
GO:0060002 plus-end directed microfilament motor activity

Biological Process:
GO:0007018 microtubule-based movement
GO:0032465 regulation of cytokinesis
GO:0034642 mitochondrion migration along actin filament
GO:0090140 regulation of mitochondrial fission

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016459 myosin complex


-  Descriptions from all associated GenBank mRNAs
  AB209035 - Homo sapiens mRNA for myosin head domain containing 1 variant protein.
AK293903 - Homo sapiens cDNA FLJ61691 complete cds, highly similar to Homo sapiens myosin head domain containing 1 (MYOHD1), transcript variant 2, mRNA.
AL133017 - Homo sapiens mRNA; cDNA DKFZp434E0727 (from clone DKFZp434E0727).
BC008900 - Homo sapiens myosin XIX, mRNA (cDNA clone MGC:14882 IMAGE:3629870), complete cds.
AK304073 - Homo sapiens cDNA FLJ61052 complete cds, highly similar to Homo sapiens myosin head domain containing 1 (MYOHD1), transcript variant 2, mRNA.
KJ899616 - Synthetic construct Homo sapiens clone ccsbBroadEn_09010 MYO19 gene, encodes complete protein.
JD243042 - Sequence 224066 from Patent EP1572962.
JD501854 - Sequence 482878 from Patent EP1572962.
JD327859 - Sequence 308883 from Patent EP1572962.
AY545559 - Homo sapiens hypothetical protein mRNA, partial cds.
JD457731 - Sequence 438755 from Patent EP1572962.
JD173585 - Sequence 154609 from Patent EP1572962.
JD098788 - Sequence 79812 from Patent EP1572962.
JD156898 - Sequence 137922 from Patent EP1572962.
JD477814 - Sequence 458838 from Patent EP1572962.
JD477813 - Sequence 458837 from Patent EP1572962.
BC036325 - Homo sapiens myosin XIX, mRNA (cDNA clone IMAGE:5194570), with apparent retained intron.
AK026518 - Homo sapiens cDNA: FLJ22865 fis, clone KAT02171.
AK299802 - Homo sapiens cDNA FLJ61374 complete cds, highly similar to Homo sapiens myosin head domain containing 1 (MYOHD1), transcript variant 3, mRNA.
CU679175 - Synthetic construct Homo sapiens gateway clone IMAGE:100020415 5' read MYOHD1 mRNA.
JD203302 - Sequence 184326 from Patent EP1572962.
JD555482 - Sequence 536506 from Patent EP1572962.
JD238631 - Sequence 219655 from Patent EP1572962.
JD036960 - Sequence 17984 from Patent EP1572962.
JD518763 - Sequence 499787 from Patent EP1572962.
JD264812 - Sequence 245836 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000614623.1, ENST00000614623.2, ENST00000614623.3, ENST00000614623.4, MYO19 , MYO19_HUMAN, MYOHD1 , NM_001163735, Q59GS4, Q96H55, Q9H5X2, uc327pjk.1, uc327pjk.2
UCSC ID: ENST00000614623.5_7
RefSeq Accession: NM_001163735.2
Protein: Q96H55 (aka MYO19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.