ID:MYO3A_HUMAN DESCRIPTION: RecName: Full=Myosin-IIIa; EC=2.7.11.1; FUNCTION: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas. DISEASE: Defects in MYO3A are the cause of deafness autosomal recessive type 30 (DFNB30) [MIM:607101]. DFNB30 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. SIMILARITY: In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. SIMILARITY: Contains 3 IQ domains. SIMILARITY: Contains 1 myosin head-like domain. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00063 - Myosin head (motor domain) PF00069 - Protein kinase domain PF00612 - IQ calmodulin-binding motif PF07714 - Protein tyrosine and serine/threonine kinase
ModBase Predicted Comparative 3D Structure on Q8NEV4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.