ID:MYO9B_HUMAN DESCRIPTION: RecName: Full=Unconventional myosin-IXb; AltName: Full=Unconventional myosin-9b; FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. INTERACTION: Q9Y6D6:ARFGEF1; NbExp=2; IntAct=EBI-6251250, EBI-1044254; SUBCELLULAR LOCATION: Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. TISSUE SPECIFICITY: Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung. DISEASE: Genetic variation in MYO9B is the cause of susceptibility to celiac disease type 4 (CELIAC4) [MIM:609753]. It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. SIMILARITY: Contains 4 IQ domains. SIMILARITY: Contains 1 myosin head-like domain. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SIMILARITY: Contains 1 Ras-associating domain. SIMILARITY: Contains 1 Rho-GAP domain. CAUTION: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9). SEQUENCE CAUTION: Sequence=AAC50402.1; Type=Miscellaneous discrepancy; Note=The C-terminal sequence from position 1917 onwards appears to be not correctly spliced; Sequence=BAA92132.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Wikipedia; Note=MYO9B entry; URL="http://en.wikipedia.org/wiki/MYO9B";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13459
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007018 microtubule-based movement GO:0007165 signal transduction GO:0007266 Rho protein signal transduction GO:0030048 actin filament-based movement GO:0035023 regulation of Rho protein signal transduction GO:0035385 Roundabout signaling pathway GO:0035556 intracellular signal transduction GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0032011 ARF protein signal transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
