Human Gene NAA16 (ENST00000379406.8_4) from GENCODE V47lift37
  Description: N-alpha-acetyltransferase 16, NatA auxiliary subunit, transcript variant 1 (from RefSeq NM_024561.5)
Gencode Transcript: ENST00000379406.8_4
Gencode Gene: ENSG00000172766.19_7
Transcript (Including UTRs)
   Position: hg19 chr13:41,885,403-41,951,166 Size: 65,764 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr13:41,885,665-41,949,738 Size: 64,074 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:41,885,403-41,951,166)mRNA (may differ from genome)Protein (864 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NAA16_HUMAN
DESCRIPTION: RecName: Full=N-alpha-acetyltransferase 16, NatA auxiliary subunit; AltName: Full=NMDA receptor-regulated 1-like protein; Short=NARG1-like protein;
FUNCTION: May belong to a complex displaying N-terminal acetyltransferase activity (By similarity).
SIMILARITY: Contains 7 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.69 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 210.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.40262-0.330 Picture PostScript Text
3' UTR -351.801428-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021183 - NatA_aux_su
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF07719 - Tetratricopeptide repeat
PF12569 - NMDA receptor-regulated protein 1
PF13181 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q6N069
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGD   SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0004596 peptide alpha-N-acetyltransferase activity
GO:0016407 acetyltransferase activity

Biological Process:
GO:0006474 N-terminal protein amino acid acetylation
GO:0017196 N-terminal peptidyl-methionine acetylation
GO:0043066 negative regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050821 protein stabilization

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031415 NatA complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK291248 - Homo sapiens cDNA FLJ77538 complete cds, highly similar to Homo sapiens NMDA receptor regulated 1-like (NARG1L), transcript variant 1, mRNA.
AK097224 - Homo sapiens cDNA FLJ39905 fis, clone SPLEN2017351.
BX640665 - Homo sapiens mRNA; cDNA DKFZp686O08147 (from clone DKFZp686O08147).
BC101719 - Homo sapiens NMDA receptor regulated 1-like, mRNA (cDNA clone MGC:126768 IMAGE:8069225), complete cds.
BC101721 - Homo sapiens NMDA receptor regulated 1-like, mRNA (cDNA clone MGC:126770 IMAGE:8069227), complete cds.
BC143506 - Homo sapiens cDNA clone IMAGE:9052014, with apparent retained intron.
AL833341 - Homo sapiens mRNA; cDNA DKFZp686E0534 (from clone DKFZp686E0534).
BC017099 - Homo sapiens NMDA receptor regulated 1-like, mRNA (cDNA clone IMAGE:3357835), partial cds.
BC028112 - Homo sapiens NMDA receptor regulated 1-like, mRNA (cDNA clone IMAGE:5393042), partial cds.
KJ903178 - Synthetic construct Homo sapiens clone ccsbBroadEn_12572 NAA16 gene, encodes complete protein.
AK025707 - Homo sapiens cDNA: FLJ22054 fis, clone HEP09634.
BC064592 - Homo sapiens NMDA receptor regulated 1-like, mRNA (cDNA clone IMAGE:5759439), complete cds.
BC032318 - Homo sapiens NMDA receptor regulated 1-like, mRNA (cDNA clone IMAGE:5222662), complete cds.
CU689326 - Synthetic construct Homo sapiens gateway clone IMAGE:100018833 5' read NARG1L mRNA.
KJ906314 - Synthetic construct Homo sapiens clone ccsbBroadEn_15984 NAA16 gene, encodes complete protein.
HQ447871 - Synthetic construct Homo sapiens clone IMAGE:100071221; CCSB009741_01 NMDA receptor regulated 1-like (NARG1L) gene, encodes complete protein.
KJ904868 - Synthetic construct Homo sapiens clone ccsbBroadEn_14262 NAA16-like gene, encodes complete protein.
JD426792 - Sequence 407816 from Patent EP1572962.
JD223968 - Sequence 204992 from Patent EP1572962.
JD333617 - Sequence 314641 from Patent EP1572962.
JD250867 - Sequence 231891 from Patent EP1572962.
JD087890 - Sequence 68914 from Patent EP1572962.
CR627327 - Homo sapiens mRNA; cDNA DKFZp686G1847 (from clone DKFZp686G1847).
JD291401 - Sequence 272425 from Patent EP1572962.
JD363626 - Sequence 344650 from Patent EP1572962.
JD561315 - Sequence 542339 from Patent EP1572962.
JD481309 - Sequence 462333 from Patent EP1572962.
JD179607 - Sequence 160631 from Patent EP1572962.
JD209926 - Sequence 190950 from Patent EP1572962.
JD386961 - Sequence 367985 from Patent EP1572962.
JD158934 - Sequence 139958 from Patent EP1572962.
JD158932 - Sequence 139956 from Patent EP1572962.
JD158933 - Sequence 139957 from Patent EP1572962.
JD208725 - Sequence 189749 from Patent EP1572962.
JD208726 - Sequence 189750 from Patent EP1572962.
JD112120 - Sequence 93144 from Patent EP1572962.
JD112121 - Sequence 93145 from Patent EP1572962.
JD382323 - Sequence 363347 from Patent EP1572962.
JD274641 - Sequence 255665 from Patent EP1572962.
JD052039 - Sequence 33063 from Patent EP1572962.
JD388097 - Sequence 369121 from Patent EP1572962.
JD339932 - Sequence 320956 from Patent EP1572962.
JD179811 - Sequence 160835 from Patent EP1572962.
JD170468 - Sequence 151492 from Patent EP1572962.
JD362514 - Sequence 343538 from Patent EP1572962.
JD467918 - Sequence 448942 from Patent EP1572962.
JD561995 - Sequence 543019 from Patent EP1572962.
JD435103 - Sequence 416127 from Patent EP1572962.
JD507106 - Sequence 488130 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B0QZ59, ENST00000379406.1, ENST00000379406.2, ENST00000379406.3, ENST00000379406.4, ENST00000379406.5, ENST00000379406.6, ENST00000379406.7, NAA16_HUMAN, NARG1L, NAT2, NM_024561, Q5VSP9, Q6N069, Q6P2D5, Q8N5J3, Q8N870, uc318oyk.1, uc318oyk.2
UCSC ID: ENST00000379406.8_4
RefSeq Accession: NM_024561.5
Protein: Q6N069 (aka NAA16_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.