Human Gene NACA (ENST00000454682.6_9) from GENCODE V47lift37
  Description: nascent polypeptide associated complex subunit alpha, transcript variant 7 (from RefSeq NM_001365896.1)
Gencode Transcript: ENST00000454682.6_9
Gencode Gene: ENSG00000196531.14_16
Transcript (Including UTRs)
   Position: hg19 chr12:57,106,211-57,119,083 Size: 12,873 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr12:57,106,322-57,118,305 Size: 11,984 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:57,106,211-57,119,083)mRNA (may differ from genome)Protein (2078 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: E9PAV3_HUMAN
DESCRIPTION: SubName: Full=Nascent polypeptide-associated complex subunit alpha;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NACA
Diseases sorted by gene-association score: atopic dermatitis (6), dermatitis (6), skeletal muscle cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 126.67 RPKM in Ovary
Total median expression: 3053.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.1039-0.105 Picture PostScript Text
3' UTR -21.00111-0.189 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002715 - Nas_poly-pep-assoc_cplx

Pfam Domains:
PF01849 - NAC domain
PF19026 - HYPK UBA domain

SCOP Domains:
46934 - UBA-like

ModBase Predicted Comparative 3D Structure on E9PAV3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005854 nascent polypeptide-associated complex


-  Descriptions from all associated GenBank mRNAs
  AK223085 - Homo sapiens mRNA for nascent-polypeptide-associated complex alpha polypeptide variant, clone: KAT03301.
AK096699 - Homo sapiens cDNA FLJ39380 fis, clone PERIC2000387, weakly similar to Mus musculus transcriptional activator alpha-NAC (Naca) gene.
AK293209 - Homo sapiens cDNA FLJ53704 complete cds, moderately similar to Nascent polypeptide-associated complex subunit alpha.
AK090650 - Homo sapiens cDNA FLJ33331 fis, clone BRACE2000489, highly similar to Nascent polypeptide-associated complex subunit alpha.
AY034001 - Homo sapiens NAC alpha mRNA, complete cds.
BC106041 - Homo sapiens nascent polypeptide-associated complex alpha subunit, mRNA (cDNA clone IMAGE:2986158), complete cds.
AF054187 - Homo sapiens alpha NAC mRNA, complete cds.
X80909 - H.sapiens alpha NAC mRNA.
AY911673 - Homo sapiens nascent polypeptide-associated complex alpha subunit (NACA) mRNA, complete cds.
BC105120 - Homo sapiens nascent polypeptide-associated complex alpha subunit, mRNA (cDNA clone IMAGE:8144123), complete cds.
BC105122 - Homo sapiens nascent polypeptide-associated complex alpha subunit, mRNA (cDNA clone IMAGE:8144125), complete cds.
AK311904 - Homo sapiens cDNA, FLJ92170, Homo sapiens nascent-polypeptide-associated complex alpha polypeptide (NACA), mRNA.
AB463919 - Synthetic construct DNA, clone: pF1KB8216, Homo sapiens NACA gene for nascent polypeptide-associated complex alpha subunit, without stop codon, in Flexi system.
CR450295 - Homo sapiens full open reading frame cDNA clone RZPDo834C011D for gene NACA, nascent-polypeptide-associated complex alpha polypeptide; complete cds; without stopcodon.
AY605660 - Homo sapiens HSD48 mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PAV3, ENST00000454682.1, ENST00000454682.2, ENST00000454682.3, ENST00000454682.4, ENST00000454682.5, NACAM_HUMAN, NM_001365896, uc320vuq.1, uc320vuq.2
UCSC ID: ENST00000454682.6_9
RefSeq Accession: NM_001365896.1
Protein: E9PAV3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.