Human Gene NACC2 (ENST00000277554.4_8) from GENCODE V47lift37

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Description: NACC family member 2 (from RefSeq NM_144653.5)
Gencode Transcript: ENST00000277554.4_8
Gencode Gene: ENSG00000148411.8_10
Transcript (Including UTRs)
Position: hg19 chr9:138,898,383-138,987,135 Size: 88,753 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr9:138,903,362-138,942,367 Size: 39,006 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:138,898,383-138,987,135)			mRNA (may differ from genome)		Protein (587 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NACC2_HUMAN DESCRIPTION: RecName: Full=Nucleus accumbens-associated protein 2; Short=NAC-2; AltName: Full=BTB/POZ domain-containing protein 14A; SIMILARITY: Contains 1 BEN domain. SIMILARITY: Contains 1 BTB (POZ) domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NACC2 Diseases sorted by gene-association score: interstitial myocarditis (3), fiedler's myocarditis (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D000082 Acetaminophen D019256 Cadmium Chloride D002794 Choline D003042 Cocaine D004040 Dietary Carbohydrates D005492 Folic Acid D005557 Formaldehyde more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 32.55 RPKM in Brain - Spinal cord (cervical c-1) Total median expression: 662.69 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-75.00	160	-0.469	Picture	PostScript	Text
3' UTR	-2018.80	4979	-0.405	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR018379 - BEN_domain
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ

Pfam Domains:
PF00651 - BTB/POZ domain
PF10523 - BEN domain

SCOP Domains:
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q96BF6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0004407 histone deacetylase activity GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0042826 histone deacetylase binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0010608 posttranscriptional regulation of gene expression GO:0016575 histone deacetylation GO:0034629 cellular protein complex localization GO:0045892 negative regulation of transcription, DNA-templated GO:0051260 protein homooligomerization GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Cellular Component: GO:0000790 nuclear chromatin GO:0005634 nucleus GO:0005730 nucleolus GO:0005739 mitochondrion GO:0016604 nuclear body GO:0016581 NuRD complex

Descriptions from all associated GenBank mRNAs


	AK129748 - Homo sapiens cDNA FLJ26237 fis, clone CBR04649, highly similar to Stathmin. BC015649 - Homo sapiens NACC family member 2, BEN and BTB (POZ) domain containing, mRNA (cDNA clone MGC:23427 IMAGE:4654320), complete cds. DQ893474 - Synthetic construct clone IMAGE:100006104; FLH193406.01X; RZPDo839F1178D BTB (POZ) domain containing 14A (BTBD14A) gene, encodes complete protein. DQ896148 - Synthetic construct Homo sapiens clone IMAGE:100010608; FLH193402.01L; RZPDo839F1168D BTB (POZ) domain containing 14A (BTBD14A) gene, encodes complete protein. BC045702 - Homo sapiens cDNA clone IMAGE:5311129. AK055078 - Homo sapiens cDNA FLJ30516 fis, clone BRAWH2000697. AL832276 - Homo sapiens mRNA; cDNA DKFZp667B1718 (from clone DKFZp667B1718). JD414130 - Sequence 395154 from Patent EP1572962. JD231373 - Sequence 212397 from Patent EP1572962. JD038820 - Sequence 19844 from Patent EP1572962. AK056521 - Homo sapiens cDNA FLJ31959 fis, clone NT2RP7007422. AK094914 - Homo sapiens cDNA FLJ37595 fis, clone BRCOC2007864. JD548502 - Sequence 529526 from Patent EP1572962. JD283820 - Sequence 264844 from Patent EP1572962. JD155739 - Sequence 136763 from Patent EP1572962. JD282275 - Sequence 263299 from Patent EP1572962. JD104071 - Sequence 85095 from Patent EP1572962. JD466900 - Sequence 447924 from Patent EP1572962. JD063101 - Sequence 44125 from Patent EP1572962. JD161964 - Sequence 142988 from Patent EP1572962. JD169854 - Sequence 150878 from Patent EP1572962. JD146505 - Sequence 127529 from Patent EP1572962. JD472834 - Sequence 453858 from Patent EP1572962. JD550815 - Sequence 531839 from Patent EP1572962. JD310998 - Sequence 292022 from Patent EP1572962. AK308497 - Homo sapiens cDNA, FLJ98538. JD118412 - Sequence 99436 from Patent EP1572962. JD233997 - Sequence 215021 from Patent EP1572962. JD340192 - Sequence 321216 from Patent EP1572962. JD457127 - Sequence 438151 from Patent EP1572962. JD210029 - Sequence 191053 from Patent EP1572962. JD216518 - Sequence 197542 from Patent EP1572962. JD278029 - Sequence 259053 from Patent EP1572962. JD121064 - Sequence 102088 from Patent EP1572962. JD132752 - Sequence 113776 from Patent EP1572962. JD145873 - Sequence 126897 from Patent EP1572962. JD465244 - Sequence 446268 from Patent EP1572962. JD194202 - Sequence 175226 from Patent EP1572962. JD097716 - Sequence 78740 from Patent EP1572962. JD114828 - Sequence 95852 from Patent EP1572962. JD232859 - Sequence 213883 from Patent EP1572962. JD547497 - Sequence 528521 from Patent EP1572962. JD404101 - Sequence 385125 from Patent EP1572962. JD211249 - Sequence 192273 from Patent EP1572962. JD200737 - Sequence 181761 from Patent EP1572962. JD476010 - Sequence 457034 from Patent EP1572962. JD097050 - Sequence 78074 from Patent EP1572962. JD420646 - Sequence 401670 from Patent EP1572962. JD406383 - Sequence 387407 from Patent EP1572962. JD155628 - Sequence 136652 from Patent EP1572962. JD200373 - Sequence 181397 from Patent EP1572962. JD358770 - Sequence 339794 from Patent EP1572962. AK309247 - Homo sapiens cDNA, FLJ99288. JD133171 - Sequence 114195 from Patent EP1572962. JD519538 - Sequence 500562 from Patent EP1572962. JD355882 - Sequence 336906 from Patent EP1572962. JD205304 - Sequence 186328 from Patent EP1572962. JD470281 - Sequence 451305 from Patent EP1572962. JD195660 - Sequence 176684 from Patent EP1572962. JD343162 - Sequence 324186 from Patent EP1572962. JD186395 - Sequence 167419 from Patent EP1572962. JD320443 - Sequence 301467 from Patent EP1572962. JD223672 - Sequence 204696 from Patent EP1572962. JD389479 - Sequence 370503 from Patent EP1572962. JD067691 - Sequence 48715 from Patent EP1572962. JD528184 - Sequence 509208 from Patent EP1572962. JD494309 - Sequence 475333 from Patent EP1572962. JD547043 - Sequence 528067 from Patent EP1572962. JD540885 - Sequence 521909 from Patent EP1572962. JD520172 - Sequence 501196 from Patent EP1572962. JD486591 - Sequence 467615 from Patent EP1572962. JD237618 - Sequence 218642 from Patent EP1572962. JD562921 - Sequence 543945 from Patent EP1572962. JD485533 - Sequence 466557 from Patent EP1572962. JD483096 - Sequence 464120 from Patent EP1572962. JD107338 - Sequence 88362 from Patent EP1572962. JD408039 - Sequence 389063 from Patent EP1572962. JD074989 - Sequence 56013 from Patent EP1572962. JD193687 - Sequence 174711 from Patent EP1572962. JD223693 - Sequence 204717 from Patent EP1572962. JD396302 - Sequence 377326 from Patent EP1572962. JD471709 - Sequence 452733 from Patent EP1572962. JD548798 - Sequence 529822 from Patent EP1572962. JD143187 - Sequence 124211 from Patent EP1572962. JD223083 - Sequence 204107 from Patent EP1572962. AK311634 - Homo sapiens cDNA, FLJ18676. JD129539 - Sequence 110563 from Patent EP1572962. JD380657 - Sequence 361681 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: BTBD14A, ENST00000277554.1, ENST00000277554.2, ENST00000277554.3, NAC2, NACC2_HUMAN, NM_144653, Q96BF6, RBB, uc317jmz.1, uc317jmz.2 UCSC ID: ENST00000277554.4_8 RefSeq Accession: NM_144653.5 Protein: Q96BF6 (aka NACC2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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