Human Gene NAIF1 (ENST00000373078.5_7) from GENCODE V47lift37

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Description: nuclear apoptosis inducing factor 1 (from RefSeq NM_197956.4)
Gencode Transcript: ENST00000373078.5_7
Gencode Gene: ENSG00000171169.9_9
Transcript (Including UTRs)
Position: hg19 chr9:130,823,512-130,829,599 Size: 6,088 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr9:130,825,707-130,829,380 Size: 3,674 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:130,823,512-130,829,599)			mRNA (may differ from genome)		Protein (327 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NAIF1_HUMAN DESCRIPTION: RecName: Full=Nuclear apoptosis-inducing factor 1; FUNCTION: Induces apoptosis. SUBUNIT: Interacts with HARBI1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the NAIF1 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000535 Aluminum D001564 Benzo(a)pyrene D003993 Dibutyl Phthalate D013749 Tetrachlorodibenzodioxin C045950 propiconazole

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.53 RPKM in Testis Total median expression: 111.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-92.00	219	-0.420	Picture	PostScript	Text
3' UTR	-789.00	2195	-0.359	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026753 - NAIF1

Pfam Domains:
PF13873 - Myb/SANT-like DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q69YI7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0005515 protein binding Biological Process: GO:0006915 apoptotic process GO:0030308 negative regulation of cell growth GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005739 mitochondrion GO:0005829 cytosol GO:0005886 plasma membrane

Descriptions from all associated GenBank mRNAs


	BC047160 - Homo sapiens chromosome 9 open reading frame 90, mRNA (cDNA clone IMAGE:4939553), partial cds. AL833392 - Homo sapiens mRNA; cDNA DKFZp762G199 (from clone DKFZp762G199). JD282887 - Sequence 263911 from Patent EP1572962. JD153998 - Sequence 135022 from Patent EP1572962. JD141403 - Sequence 122427 from Patent EP1572962. JD043035 - Sequence 24059 from Patent EP1572962. JD372579 - Sequence 353603 from Patent EP1572962. JD095588 - Sequence 76612 from Patent EP1572962. JD499001 - Sequence 480025 from Patent EP1572962. JD362892 - Sequence 343916 from Patent EP1572962. JD053681 - Sequence 34705 from Patent EP1572962. JD231374 - Sequence 212398 from Patent EP1572962. JD443833 - Sequence 424857 from Patent EP1572962. JD108257 - Sequence 89281 from Patent EP1572962. BC013371 - Homo sapiens chromosome 9 open reading frame 90, mRNA (cDNA clone IMAGE:3929650), partial cds. JD149298 - Sequence 130322 from Patent EP1572962. AK122729 - Homo sapiens cDNA FLJ16236 fis, clone FELIV1000153. JD149299 - Sequence 130323 from Patent EP1572962. JD366280 - Sequence 347304 from Patent EP1572962. JD366281 - Sequence 347305 from Patent EP1572962. JD185300 - Sequence 166324 from Patent EP1572962. JD366278 - Sequence 347302 from Patent EP1572962. JD074590 - Sequence 55614 from Patent EP1572962. JD185297 - Sequence 166321 from Patent EP1572962. JD185298 - Sequence 166322 from Patent EP1572962. JD185299 - Sequence 166323 from Patent EP1572962. JD292537 - Sequence 273561 from Patent EP1572962. JD155805 - Sequence 136829 from Patent EP1572962. JD051525 - Sequence 32549 from Patent EP1572962. JD366282 - Sequence 347306 from Patent EP1572962. JD411174 - Sequence 392198 from Patent EP1572962. JD155804 - Sequence 136828 from Patent EP1572962. JD116840 - Sequence 97864 from Patent EP1572962. JD517382 - Sequence 498406 from Patent EP1572962. JD149295 - Sequence 130319 from Patent EP1572962. JD451955 - Sequence 432979 from Patent EP1572962. JD534572 - Sequence 515596 from Patent EP1572962. JD292477 - Sequence 273501 from Patent EP1572962. JD092067 - Sequence 73091 from Patent EP1572962. JD183894 - Sequence 164918 from Patent EP1572962. JD066617 - Sequence 47641 from Patent EP1572962. JD176412 - Sequence 157436 from Patent EP1572962. JD138410 - Sequence 119434 from Patent EP1572962. JD238312 - Sequence 219336 from Patent EP1572962. JD243166 - Sequence 224190 from Patent EP1572962. JD136107 - Sequence 117131 from Patent EP1572962. JD117500 - Sequence 98524 from Patent EP1572962. JD457007 - Sequence 438031 from Patent EP1572962. JD100563 - Sequence 81587 from Patent EP1572962. JD051351 - Sequence 32375 from Patent EP1572962. JD512066 - Sequence 493090 from Patent EP1572962. JD412500 - Sequence 393524 from Patent EP1572962. JD197689 - Sequence 178713 from Patent EP1572962. JD212260 - Sequence 193284 from Patent EP1572962. JD139140 - Sequence 120164 from Patent EP1572962. JD310804 - Sequence 291828 from Patent EP1572962. JD154862 - Sequence 135886 from Patent EP1572962. JD110109 - Sequence 91133 from Patent EP1572962. JD302225 - Sequence 283249 from Patent EP1572962. JD521887 - Sequence 502911 from Patent EP1572962. JD469108 - Sequence 450132 from Patent EP1572962. JD157240 - Sequence 138264 from Patent EP1572962. JD431925 - Sequence 412949 from Patent EP1572962. JD300592 - Sequence 281616 from Patent EP1572962. JD454785 - Sequence 435809 from Patent EP1572962. JD173683 - Sequence 154707 from Patent EP1572962. JD052665 - Sequence 33689 from Patent EP1572962. JD077098 - Sequence 58122 from Patent EP1572962. JD073387 - Sequence 54411 from Patent EP1572962. JD486656 - Sequence 467680 from Patent EP1572962. JD272786 - Sequence 253810 from Patent EP1572962. JD294992 - Sequence 276016 from Patent EP1572962. JD195582 - Sequence 176606 from Patent EP1572962. JD229369 - Sequence 210393 from Patent EP1572962. JD498696 - Sequence 479720 from Patent EP1572962. BC021580 - Homo sapiens nuclear apoptosis inducing factor 1, mRNA (cDNA clone MGC:32044 IMAGE:4810929), complete cds. KJ905037 - Synthetic construct Homo sapiens clone ccsbBroadEn_14431 NAIF1 gene, encodes complete protein. JD023084 - Sequence 4108 from Patent EP1572962. JD031753 - Sequence 12777 from Patent EP1572962. JD066135 - Sequence 47159 from Patent EP1572962. JD357097 - Sequence 338121 from Patent EP1572962. JD462151 - Sequence 443175 from Patent EP1572962. JD138960 - Sequence 119984 from Patent EP1572962. JD025923 - Sequence 6947 from Patent EP1572962. JD159402 - Sequence 140426 from Patent EP1572962. JD031594 - Sequence 12618 from Patent EP1572962. DQ600055 - Homo sapiens piRNA piR-38121, complete sequence. JD485915 - Sequence 466939 from Patent EP1572962. JD409500 - Sequence 390524 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B3KV81, C9orf90, ENST00000373078.1, ENST00000373078.2, ENST00000373078.3, ENST00000373078.4, NAIF1_HUMAN, NM_197956, Q69YI7, Q8WU12, uc318klv.1, uc318klv.2 UCSC ID: ENST00000373078.5_7 RefSeq Accession: NM_197956.4 Protein: Q69YI7 (aka NAIF1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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