ID:SNAA_HUMAN DESCRIPTION: RecName: Full=Alpha-soluble NSF attachment protein; Short=SNAP-alpha; AltName: Full=N-ethylmaleimide-sensitive factor attachment protein alpha; FUNCTION: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. SUBUNIT: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By similarity). INTERACTION: O00161:SNAP23; NbExp=2; IntAct=EBI-749652, EBI-745000; Q12846:STX4; NbExp=2; IntAct=EBI-749652, EBI-744942; SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. SIMILARITY: Belongs to the SNAP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P54920
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006891 intra-Golgi vesicle-mediated transport GO:0007420 brain development GO:0010807 regulation of synaptic vesicle priming GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0030182 neuron differentiation GO:0032781 positive regulation of ATPase activity GO:0032984 macromolecular complex disassembly GO:0035249 synaptic transmission, glutamatergic GO:0035494 SNARE complex disassembly GO:0045176 apical protein localization GO:0048208 COPII vesicle coating GO:0061025 membrane fusion
Protein P54920 (Reactome details) participates in the following event(s):
R-HSA-429815 Formation Of Bloc-1 Complex R-HSA-5694423 NSF and SNAPs bind cis-SNARE complex R-HSA-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs R-HSA-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane R-HSA-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN R-HSA-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN R-HSA-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi R-HSA-5694425 NSF ATPase activity dissociates cis-SNARE R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER R-HSA-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN R-HSA-6814683 NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN R-HSA-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane R-HSA-432722 Golgi Associated Vesicle Biogenesis R-HSA-204005 COPII-mediated vesicle transport R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811438 Intra-Golgi traffic R-HSA-421837 Clathrin derived vesicle budding R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199992 trans-Golgi Network Vesicle Budding R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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Common Gene Haplotype Alleles 
