Human Gene NARF (ENST00000309794.16_6) from GENCODE V47lift37
Description: nuclear prelamin A recognition factor, transcript variant 2 (from RefSeq NM_031968.2)
Gencode Transcript: ENST00000309794.16_6
Gencode Gene: ENSG00000141562.19_13
Transcript (Including UTRs)
Position: hg19 chr17:80,416,617-80,448,413 Size: 31,797 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr17:80,416,680-80,446,033 Size: 29,354 Coding Exon Count: 11
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: NARF_HUMAN
DESCRIPTION: RecName: Full=Nuclear prelamin A recognition factor; AltName: Full=Iron-only hydrogenase-like protein 2; Short=IOP2;
SUBUNIT: Interacts with LMNA and binds to the farnesylated C- terminal domain.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Belongs to the NARF family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR009016 - Fe_hydrogenase
IPR004108 - Fe_hydrogenase_lsu_C
IPR003149 - Fe_hydrogenase_ssu-like
Pfam Domains: PF02256 - Iron hydrogenase small subunit
PF02906 - Iron only hydrogenase large subunit, C-terminal domain
SCOP Domains: 48674 - Fe-only hydrogenase smaller subunit
53920 - Fe-only hydrogenase
ModBase Predicted Comparative 3D Structure on Q9UHQ1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK056966 - Homo sapiens cDNA FLJ32404 fis, clone SKMUS2000380, highly similar to Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 1, mRNA.AK297875 - Homo sapiens cDNA FLJ52706 complete cds, moderately similar to Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 1, mRNA.BC000438 - Homo sapiens nuclear prelamin A recognition factor, mRNA (cDNA clone MGC:8398 IMAGE:2820621), complete cds.AK307351 - Homo sapiens cDNA, FLJ97299.AK303155 - Homo sapiens cDNA FLJ55037 complete cds, highly similar to Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 1, mRNA.AK000929 - Homo sapiens cDNA FLJ10067 fis, clone HEMBA1001526, weakly similar to PERIPLASMIC [FE] HYDROGENASE 1 (EC 1.18.99.1).AF128406 - Homo sapiens nuclear prelamin A recognition factor mRNA, complete cds.BC016440 - Homo sapiens nuclear prelamin A recognition factor, mRNA (cDNA clone MGC:17011 IMAGE:3447710), complete cds.CU674220 - Synthetic construct Homo sapiens gateway clone IMAGE:100017373 5' read NARF mRNA.CU677625 - Synthetic construct Homo sapiens gateway clone IMAGE:100017204 5' read NARF mRNA.HQ448225 - Synthetic construct Homo sapiens clone IMAGE:100071626; CCSB003176_01 nuclear prelamin A recognition factor (NARF) gene, encodes complete protein.KJ898624 - Synthetic construct Homo sapiens clone ccsbBroadEn_08018 NARF gene, encodes complete protein.KJ898625 - Synthetic construct Homo sapiens clone ccsbBroadEn_08019 NARF gene, encodes complete protein.AL137729 - Homo sapiens mRNA; cDNA DKFZp434G0420 (from clone DKFZp434G0420).AK093717 - Homo sapiens cDNA FLJ36398 fis, clone THYMU2009592, highly similar to Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 1, mRNA.AX748274 - Sequence 1799 from Patent EP1308459.EF601655 - Homo sapiens clone 1 nuclear prelamin A recognition factor (NARF) mRNA, partial cds.EF601656 - Homo sapiens clone 2 nuclear prelamin A recognition factor (NARF) mRNA, partial cds.JD110890 - Sequence 91914 from Patent EP1572962.JD180492 - Sequence 161516 from Patent EP1572962.JD534137 - Sequence 515161 from Patent EP1572962.JD254736 - Sequence 235760 from Patent EP1572962.JD098258 - Sequence 79282 from Patent EP1572962.JD317426 - Sequence 298450 from Patent EP1572962.JD104174 - Sequence 85198 from Patent EP1572962.JD384946 - Sequence 365970 from Patent EP1572962.JD098258 - Sequence 79282 from Patent EP1572962.JD317426 - Sequence 298450 from Patent EP1572962.JD104174 - Sequence 85198 from Patent EP1572962.JD203980 - Sequence 185004 from Patent EP1572962.JD368058 - Sequence 349082 from Patent EP1572962.JD305916 - Sequence 286940 from Patent EP1572962.JD281478 - Sequence 262502 from Patent EP1572962.JD492084 - Sequence 473108 from Patent EP1572962.JD032304 - Sequence 13328 from Patent EP1572962.JD293436 - Sequence 274460 from Patent EP1572962.JD417041 - Sequence 398065 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A6NCJ3, B3KPX2, ENST00000309794.1, ENST00000309794.10, ENST00000309794.11, ENST00000309794.12, ENST00000309794.13, ENST00000309794.14, ENST00000309794.15, ENST00000309794.2, ENST00000309794.3, ENST00000309794.4, ENST00000309794.5, ENST00000309794.6, ENST00000309794.7, ENST00000309794.8, ENST00000309794.9, K4DI98, NARF_HUMAN, NM_031968, Q96AY9, Q9BWC6, Q9UHQ1, uc317opi.1, uc317opi.2UCSC ID: ENST00000309794.16_6RefSeq Accession: NM_012336.4
Protein: Q9UHQ1
(aka NARF_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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