ID:ARY1_HUMAN DESCRIPTION: RecName: Full=Arylamine N-acetyltransferase 1; EC=2.3.1.5; AltName: Full=Arylamide acetylase 1; AltName: Full=Monomorphic arylamine N-acetyltransferase; Short=MNAT; AltName: Full=N-acetyltransferase type 1; Short=NAT-1; FUNCTION: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. CATALYTIC ACTIVITY: Acetyl-CoA + an arylamine = CoA + an N- acetylarylamine. SUBCELLULAR LOCATION: Cytoplasm. POLYMORPHISM: N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N- acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder. MISCELLANEOUS: NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme. SIMILARITY: Belongs to the arylamine N-acetyltransferase family. CAUTION: The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee. WEB RESOURCE: Name=NAT; Note=NAT alleles; URL="http://www.louisville.edu/medschool/pharmacology/NAT.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nat1/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18440
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
