Human Gene NCOA7 (ENST00000392477.7_8) from GENCODE V47lift37

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Description: nuclear receptor coactivator 7, transcript variant 1 (from RefSeq NM_181782.5)
Gencode Transcript: ENST00000392477.7_8
Gencode Gene: ENSG00000111912.20_16
Transcript (Including UTRs)
Position: hg19 chr6:126,112,106-126,253,180 Size: 141,075 Total Exon Count: 16 Strand: +
Coding Region
Position: hg19 chr6:126,136,501-126,249,917 Size: 113,417 Coding Exon Count: 15

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:126,112,106-126,253,180)			mRNA (may differ from genome)		Protein (942 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NCOA7_HUMAN DESCRIPTION: RecName: Full=Nuclear receptor coactivator 7; AltName: Full=140 kDa estrogen receptor-associated protein; AltName: Full=Estrogen nuclear receptor coactivator 1; FUNCTION: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. SUBUNIT: Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR- ARNT. INTERACTION: P35869:AHR; NbExp=2; IntAct=EBI-80799, EBI-80780; P27540:ARNT; NbExp=2; IntAct=EBI-80799, EBI-80809; O95166:GABARAP; NbExp=4; IntAct=EBI-80799, EBI-712001; Q9H0R8:GABARAPL1; NbExp=2; IntAct=EBI-80799, EBI-746969; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line. SIMILARITY: Belongs to the OXR1 family. SIMILARITY: Contains 1 LysM repeat. SIMILARITY: Contains 1 TLD domain. SEQUENCE CAUTION: Sequence=CAD89948.1; Type=Frameshift; Positions=782;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NCOA7 Diseases sorted by gene-association score: brugada syndrome (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C103505 AM 251 D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D002794 Choline D003300 Copper D019327 Copper Sulfate D003375 Coumestrol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 18.09 RPKM in Brain - Cerebellar Hemisphere Total median expression: 371.87 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-42.00	172	-0.244	Picture	PostScript	Text
3' UTR	-794.20	3263	-0.243	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004182 - GRAM
IPR018392 - Peptidoglycan-bd_lysin
IPR002482 - Peptidoglycan-bd_Lysin_subgr
IPR006571 - TLDc

Pfam Domains:
PF01476 - LysM domain
PF07534 - TLD

SCOP Domains:
54106 - LysM domain

ModBase Predicted Comparative 3D Structure on Q8NI08


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details			Gene Details
Gene Sorter	Gene Sorter			Gene Sorter
	RGD			WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0035257 nuclear hormone receptor binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1900408 negative regulation of cellular response to oxidative stress GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation GO:1903204 negative regulation of oxidative stress-induced neuron death Cellular Component: GO:0005622 intracellular GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AF493978 - Homo sapiens 140 kDa estrogen receptor associated protein mRNA, complete cds. BC137094 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone MGC:168714 IMAGE:9021091), complete cds. BC137095 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone MGC:168715 IMAGE:9021092), complete cds. AK127512 - Homo sapiens cDNA FLJ45605 fis, clone BRTHA3021971, highly similar to Nuclear receptor coactivator 7. AK294558 - Homo sapiens cDNA FLJ53471 complete cds, highly similar to Nuclear receptor coactivator 7. BX537385 - Homo sapiens mRNA; cDNA DKFZp686O06111 (from clone DKFZp686O06111); complete cds. AL832621 - Homo sapiens mRNA; cDNA DKFZp451P0217 (from clone DKFZp451P0217). AL832628 - Homo sapiens mRNA; cDNA DKFZp451D1618 (from clone DKFZp451D1618). AM393179 - Synthetic construct Homo sapiens clone IMAGE:100002320 for hypothetical protein (NCOA7 gene). AM393484 - Synthetic construct Homo sapiens clone IMAGE:100002733 for hypothetical protein (NCOA7 gene). AM392895 - Synthetic construct Homo sapiens clone IMAGE:100002981 for hypothetical protein (NCOA7 gene). AM393507 - Synthetic construct Homo sapiens clone IMAGE:100002980 for hypothetical protein (NCOA7 gene). AM393871 - Synthetic construct Homo sapiens clone IMAGE:100002979 for hypothetical protein (NCOA7 gene). AL834442 - Homo sapiens mRNA; cDNA DKFZp761B2210 (from clone DKFZp761B2210). BC033612 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4997115), partial cds. AJ420542 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1090104. AK307395 - Homo sapiens cDNA, FLJ97343. BC036461 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4818332), complete cds. AB074157 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla10993, full insert sequence. AB074156 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla00052, full insert sequence. BC071782 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4609474), complete cds. KJ903788 - Synthetic construct Homo sapiens clone ccsbBroadEn_13182 NCOA7 gene, encodes complete protein. LF322086 - JP 2014500723-A/129589: Polycomb-Associated Non-Coding RNAs. LF322083 - JP 2014500723-A/129586: Polycomb-Associated Non-Coding RNAs. BC009399 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4132089), partial cds. LF322080 - JP 2014500723-A/129583: Polycomb-Associated Non-Coding RNAs. LF322079 - JP 2014500723-A/129582: Polycomb-Associated Non-Coding RNAs. MA557663 - JP 2018138019-A/129589: Polycomb-Associated Non-Coding RNAs. MA557660 - JP 2018138019-A/129586: Polycomb-Associated Non-Coding RNAs. MA557657 - JP 2018138019-A/129583: Polycomb-Associated Non-Coding RNAs. MA557656 - JP 2018138019-A/129582: Polycomb-Associated Non-Coding RNAs. AY364254 - Homo sapiens clone peg2403 hypothetical protein mRNA, partial cds. LF322072 - JP 2014500723-A/129575: Polycomb-Associated Non-Coding RNAs. LF322071 - JP 2014500723-A/129574: Polycomb-Associated Non-Coding RNAs. KC238672 - Homo sapiens NCOA7-AS (NCOA7) mRNA, complete cds. AK094706 - Homo sapiens cDNA FLJ37387 fis, clone BRAMY2026685, moderately similar to Homo sapiens oxidation protection protein (OXR1) mRNA. JD500564 - Sequence 481588 from Patent EP1572962. JD190713 - Sequence 171737 from Patent EP1572962. JD335254 - Sequence 316278 from Patent EP1572962. JD290737 - Sequence 271761 from Patent EP1572962. JD091710 - Sequence 72734 from Patent EP1572962. JD428797 - Sequence 409821 from Patent EP1572962. JD094334 - Sequence 75358 from Patent EP1572962. JD171858 - Sequence 152882 from Patent EP1572962. JD327966 - Sequence 308990 from Patent EP1572962. JD357255 - Sequence 338279 from Patent EP1572962. JD548749 - Sequence 529773 from Patent EP1572962. JD321317 - Sequence 302341 from Patent EP1572962. JD556994 - Sequence 538018 from Patent EP1572962. BC039853 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:5738565), with apparent retained intron. JD306747 - Sequence 287771 from Patent EP1572962. JD118732 - Sequence 99756 from Patent EP1572962. JD110557 - Sequence 91581 from Patent EP1572962. JD110558 - Sequence 91582 from Patent EP1572962. JD454123 - Sequence 435147 from Patent EP1572962. JD347050 - Sequence 328074 from Patent EP1572962. JD376122 - Sequence 357146 from Patent EP1572962. JD404886 - Sequence 385910 from Patent EP1572962. JD536211 - Sequence 517235 from Patent EP1572962. JD179209 - Sequence 160233 from Patent EP1572962. JD376819 - Sequence 357843 from Patent EP1572962. JD482993 - Sequence 464017 from Patent EP1572962. JD135689 - Sequence 116713 from Patent EP1572962. JD238033 - Sequence 219057 from Patent EP1572962. JD047484 - Sequence 28508 from Patent EP1572962. JD530830 - Sequence 511854 from Patent EP1572962. JD171593 - Sequence 152617 from Patent EP1572962. JD047855 - Sequence 28879 from Patent EP1572962. JD086270 - Sequence 67294 from Patent EP1572962. JD096468 - Sequence 77492 from Patent EP1572962. JD308953 - Sequence 289977 from Patent EP1572962. JD332456 - Sequence 313480 from Patent EP1572962. JD448484 - Sequence 429508 from Patent EP1572962. JD352062 - Sequence 333086 from Patent EP1572962. JD257683 - Sequence 238707 from Patent EP1572962. JD144021 - Sequence 125045 from Patent EP1572962. JD230101 - Sequence 211125 from Patent EP1572962. JD433724 - Sequence 414748 from Patent EP1572962. JD492851 - Sequence 473875 from Patent EP1572962. LF322068 - JP 2014500723-A/129571: Polycomb-Associated Non-Coding RNAs. JD244994 - Sequence 226018 from Patent EP1572962. MA557649 - JP 2018138019-A/129575: Polycomb-Associated Non-Coding RNAs. MA557648 - JP 2018138019-A/129574: Polycomb-Associated Non-Coding RNAs. MA557645 - JP 2018138019-A/129571: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B2RNS2, B7Z2C4, B9EH71, ENST00000392477.1, ENST00000392477.2, ENST00000392477.3, ENST00000392477.4, ENST00000392477.5, ENST00000392477.6, ERAP140, ESNA1, G8JL91, Nbla00052, Nbla10993, NCOA7_HUMAN, NM_181782, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08, uc318vcw.1, uc318vcw.2 UCSC ID: ENST00000392477.7_8 RefSeq Accession: NM_181782.5 Protein: Q8NI08 (aka NCOA7_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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