ID:NCOR1_HUMAN DESCRIPTION: RecName: Full=Nuclear receptor corepressor 1; Short=N-CoR; Short=N-CoR1; FUNCTION: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. SUBUNIT: Interacts with C1D, SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains. SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is faciliated with RARA trimethylation. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and KDM3A. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with HDAC9 (via its catalytic domain). Interacts with CBFA2T3 and HEXIM1. Interacts (via the RRFD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. INTERACTION: Q9UI36:DACH1; NbExp=2; IntAct=EBI-347233, EBI-347111; O15379:HDAC3; NbExp=2; IntAct=EBI-347233, EBI-607682; P10276:RARA; NbExp=3; IntAct=EBI-347233, EBI-413374; Q13263:TRIM28; NbExp=4; IntAct=EBI-347233, EBI-78139; SUBCELLULAR LOCATION: Nucleus (By similarity). DOMAIN: The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3). DOMAIN: The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity). PTM: Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation (By similarity). SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family. SIMILARITY: Contains 2 SANT domains. SEQUENCE CAUTION: Sequence=BAA82999.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75376
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0003677 DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0016922 ligand-dependent nuclear receptor binding GO:0035257 nuclear hormone receptor binding GO:0042826 histone deacetylase binding GO:0044212 transcription regulatory region DNA binding GO:0046966 thyroid hormone receptor binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007623 circadian rhythm GO:0019216 regulation of lipid metabolic process GO:0046329 negative regulation of JNK cascade GO:0051225 spindle assembly GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:2000191 regulation of fatty acid transport
BC167431 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone MGC:166905 IMAGE:8860107), complete cds. AF087856 - Homo sapiens nuclear receptor co-repressor mRNA, complete cds. AB028970 - Homo sapiens KIAA1047 mRNA for KIAA1047 protein. AB019524 - Homo sapiens mRNA for nuclear receptor co-repressor, partial cds. AF044209 - Homo sapiens nuclear receptor co-repressor N-CoR mRNA, complete cds. BC172437 - Synthetic construct Homo sapiens clone IMAGE:100069131, MGC:199142 nuclear receptor co-repressor 1 (NCOR1) mRNA, encodes complete protein. AB385422 - Synthetic construct DNA, clone: pF1KA1047, Homo sapiens NCOR1 gene for nuclear receptor corepressor 1, complete cds, without stop codon, in Flexi system. AB028450 - Homo sapiens mRNA for nuclear receptor co-repressor isoform 1, partial cds. AK024136 - Homo sapiens cDNA FLJ14074 fis, clone HEMBB1001869. LF211498 - JP 2014500723-A/19001: Polycomb-Associated Non-Coding RNAs. AF303584 - Homo sapiens NCOR isoform d mRNA, complete cds. AF303585 - Homo sapiens NCOR isoform c mRNA, complete cds. AL137641 - Homo sapiens mRNA; cDNA DKFZp434M075 (from clone DKFZp434M075). JD165058 - Sequence 146082 from Patent EP1572962. AK310405 - Homo sapiens cDNA, FLJ17447. LF380481 - JP 2014500723-A/187984: Polycomb-Associated Non-Coding RNAs. AK295893 - Homo sapiens cDNA FLJ52302 complete cds, highly similar to Nuclear receptor corepressor 1. LF380480 - JP 2014500723-A/187983: Polycomb-Associated Non-Coding RNAs. JD205105 - Sequence 186129 from Patent EP1572962. JD533522 - Sequence 514546 from Patent EP1572962. LF380479 - JP 2014500723-A/187982: Polycomb-Associated Non-Coding RNAs. AB028451 - Homo sapiens mRNA for nuclear receptor co-repressor isoform 2, partial cds. AK302746 - Homo sapiens cDNA FLJ50924 partial cds, highly similar to Nuclear receptor corepressor 1. MA447075 - JP 2018138019-A/19001: Polycomb-Associated Non-Coding RNAs. MA616058 - JP 2018138019-A/187984: Polycomb-Associated Non-Coding RNAs. MA616057 - JP 2018138019-A/187983: Polycomb-Associated Non-Coding RNAs. MA616056 - JP 2018138019-A/187982: Polycomb-Associated Non-Coding RNAs. AF303586 - Homo sapiens NCOR isoform b mRNA, complete cds. BC050594 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:6024800), partial cds. AK307614 - Homo sapiens cDNA, FLJ97562. BC035748 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:5749816), with apparent retained intron. BC026028 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:3836580), partial cds. BC058511 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:5190073), partial cds. BC142648 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:40147982), partial cds. BC068996 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:5474358), partial cds. BC056862 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:3904576), partial cds. BC107772 - Homo sapiens nuclear receptor co-repressor 1, mRNA (cDNA clone IMAGE:6451988), complete cds. JD276390 - Sequence 257414 from Patent EP1572962. JD309658 - Sequence 290682 from Patent EP1572962. JD542125 - Sequence 523149 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_vdrPathway - Control of Gene Expression by Vitamin D Receptor h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
Reactome (by CSHL, EBI, and GO)
Protein O75376 (Reactome details) participates in the following event(s):
R-HSA-381290 PPARG:RXRA heterodimer binds to PPARG corepressors R-HSA-1368069 NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors. R-HSA-5663245 NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors R-HSA-5663252 NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors R-HSA-5663258 NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors R-HSA-5663265 NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors R-HSA-5663271 NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands R-HSA-173481 SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling R-HSA-2186747 Ubiquitination of SKI/SKIL by RNF111/SMURF2 R-NUL-2186755 Ubiquitination of SKI/SKIL by Rnf111 R-HSA-400183 PPARA:RXRA heterodimer recruits corepressors R-HSA-400143 Fatty acid ligands activate PPARA R-HSA-1253325 ERBB4s80 binds TAB2:NCOR1 complex R-HSA-8954182 ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter R-HSA-8954185 ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter R-HSA-1253319 ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus R-NUL-2186736 Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation R-HSA-2186741 SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL R-HSA-1912388 NICD1 displaces co-repressor complex from RBPJ (CSL) R-HSA-2220982 NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) R-NUL-2064264 NICD1 displaces NCOR co-repressor complex from CSL R-HSA-3777129 HDAC3 containing complexes deacetylate histone R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-400253 Circadian Clock R-HSA-1368071 NR1D1 (REV-ERBA) represses gene expression R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-1266738 Developmental Biology R-HSA-5619507 Activation of HOX genes during differentiation R-HSA-1251985 Nuclear signaling by ERBB4 R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-556833 Metabolism of lipids R-HSA-1236394 Signaling by ERBB4 R-HSA-1980143 Signaling by NOTCH1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-3214815 HDACs deacetylate histones R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-212436 Generic Transcription Pathway R-HSA-1430728 Metabolism R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-157118 Signaling by NOTCH R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-3247509 Chromatin modifying enzymes R-HSA-9006936 Signaling by TGF-beta family members R-HSA-73857 RNA Polymerase II Transcription R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-4839726 Chromatin organization R-HSA-74160 Gene expression (Transcription) R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
