ID:NDRG2_HUMAN DESCRIPTION: RecName: Full=Protein NDRG2; AltName: Full=N-myc downstream-regulated gene 2 protein; AltName: Full=Protein Syld709613; FUNCTION: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. SUBUNIT: Interacts with CTNNB1. INTERACTION: P03372:ESR1; NbExp=2; IntAct=EBI-3895741, EBI-78473; SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone (By similarity). Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). TISSUE SPECIFICITY: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). DEVELOPMENTAL STAGE: Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development. SIMILARITY: Belongs to the NDRG family. CAUTION: Has some similarity to hydrolases, but lacks the conserved Ser-His-Asp catalytic triad. Has no hydrolase activity towards p-nitrophenylbutyrate (in vitro). SEQUENCE CAUTION: Sequence=BAA86562.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD62350.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NDRG2ID41513ch14q11.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UN36
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001818 negative regulation of cytokine production GO:0007165 signal transduction GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0010574 regulation of vascular endothelial growth factor production GO:0016055 Wnt signaling pathway GO:0021762 substantia nigra development GO:0030154 cell differentiation GO:0048662 negative regulation of smooth muscle cell proliferation GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0090361 regulation of platelet-derived growth factor production
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
