ID:NDUA2_HUMAN DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; AltName: Full=Complex I-B8; Short=CI-B8; AltName: Full=NADH-ubiquinone oxidoreductase B8 subunit; FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. SUBUNIT: Complex I is composed of 45 different subunits. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43678
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0032981 mitochondrial respiratory chain complex I assembly GO:0055114 oxidation-reduction process
LP895537 - Sequence 401 from Patent EP3253886. AF047185 - Homo sapiens NADH-ubiquinone oxidoreductase subunit CI-B8 mRNA, complete cds. AF077029 - Homo sapiens NADH-ubiquinone oxidoreductase B8 subunit mRNA, nuclear gene encoding mitochondrial protein, complete cds. JD391205 - Sequence 372229 from Patent EP1572962. JD506683 - Sequence 487707 from Patent EP1572962. BC003674 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa, mRNA (cDNA clone MGC:12315 IMAGE:4044385), complete cds. JD305646 - Sequence 286670 from Patent EP1572962. JD500737 - Sequence 481761 from Patent EP1572962. JD040050 - Sequence 21074 from Patent EP1572962. JD064749 - Sequence 45773 from Patent EP1572962. KJ904515 - Synthetic construct Homo sapiens clone ccsbBroadEn_13909 NDUFA2 gene, encodes complete protein. CR457016 - Homo sapiens full open reading frame cDNA clone RZPDo834H035D for gene CD14, CD14 antigen; complete cds, incl. stopcodon. AK311095 - Homo sapiens cDNA, FLJ18137.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)
Reactome (by CSHL, EBI, and GO)
Protein O43678 (Reactome details) participates in the following event(s):
R-HSA-6799178 Intermediate 1 binds HP subcomplex to form Intermediate 2 R-HSA-6799191 Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex R-HSA-6799202 The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex R-HSA-6799197 ND4, ND5 bind the 550kDa complex to form the 815kDa complex R-HSA-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex R-HSA-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I R-HSA-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2 R-HSA-6799198 Complex I biogenesis R-HSA-611105 Respiratory electron transport R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
