ID:NDUA4_HUMAN DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4; AltName: Full=Complex I-MLRQ; Short=CI-MLRQ; AltName: Full=NADH-ubiquinone oxidoreductase MLRQ subunit; FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. SUBUNIT: Mammalian complex I is composed of 45 different subunits. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. SIMILARITY: Belongs to the complex I NDUFA4 subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00483
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0055114 oxidation-reduction process GO:1902600 hydrogen ion transmembrane transport
JD273009 - Sequence 254033 from Patent EP1572962. AF201077 - Homo sapiens NADH:ubiquinone oxidoreductase MLRQ subunit (NDUFA4) mRNA, complete cds. AK024837 - Homo sapiens cDNA: FLJ21184 fis, clone CAS11635. AK130950 - Homo sapiens cDNA FLJ27440 fis, clone CBL02355, highly similar to NADH-ubiquinone oxidoreductase MLRQ subunit (EC 1.6.5.3). BC105295 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, mRNA (cDNA clone MGC:104422 IMAGE:6739636), complete cds. U94586 - Homo sapiens NADH:ubiquinone oxidoreductase MLRQ subunit mRNA, complete cds. JD528746 - Sequence 509770 from Patent EP1572962. BC101794 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, mRNA (cDNA clone MGC:126843 IMAGE:8069300), complete cds. BC101796 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, mRNA (cDNA clone MGC:126845 IMAGE:8069302), complete cds. CR541716 - Homo sapiens full open reading frame cDNA clone RZPDo834D0529D for gene NDUFA4, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa; complete cds, incl. stopcodon. KJ891672 - Synthetic construct Homo sapiens clone ccsbBroadEn_01066 NDUFA4 gene, encodes complete protein. CR407618 - Homo sapiens full open reading frame cDNA clone RZPDo834A1116D for gene NDUFA4, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa complete cds, without stopcodon. JD259316 - Sequence 240340 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)
Reactome (by CSHL, EBI, and GO)
Protein O00483 (Reactome details) participates in the following event(s):
R-HSA-163214 Electron transfer from reduced cytochrome c to molecular oxygen R-HSA-611105 Respiratory electron transport R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-212436 Generic Transcription Pathway R-HSA-1430728 Metabolism R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
