Human Gene NDUFS6 (ENST00000274137.10_4) from GENCODE V47lift37
  Description: NADH:ubiquinone oxidoreductase subunit S6 (from RefSeq NM_004553.6)
Gencode Transcript: ENST00000274137.10_4
Gencode Gene: ENSG00000145494.12_6
Transcript (Including UTRs)
   Position: hg19 chr5:1,801,521-1,816,162 Size: 14,642 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr5:1,801,532-1,816,030 Size: 14,499 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:1,801,521-1,816,162)mRNA (may differ from genome)Protein (124 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NDUFS6
Diseases sorted by gene-association score: mitochondrial complex i deficiency* (960), leigh syndrome (3), mitochondrial metabolism disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 63.27 RPKM in Heart - Left Ventricle
Total median expression: 1226.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -48.90132-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016668 - NADH_Ub_cplx-1_Fe-S_6_mit
IPR019401 - Znf_CHCC

Pfam Domains:
PF10276 - Zinc-finger domain

SCOP Domains:
57802 - Rubredoxin-like

ModBase Predicted Comparative 3D Structure on Q6IBC4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0006631 fatty acid metabolic process
GO:0006936 muscle contraction
GO:0010259 multicellular organism aging
GO:0022904 respiratory electron transport chain
GO:0035264 multicellular organism growth
GO:0055114 oxidation-reduction process
GO:0061458 reproductive system development
GO:0070584 mitochondrion morphogenesis
GO:0072358 cardiovascular system development

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0016020 membrane
GO:0070469 respiratory chain


-  Descriptions from all associated GenBank mRNAs
  AK022503 - Homo sapiens cDNA FLJ12441 fis, clone NT2RM1000132, highly similar to NADH-ubiquinone oxidoreductase 13 kDa-A subunit, mitochondrial precursor (EC 1.6.5.3).
BC038664 - Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase), mRNA (cDNA clone MGC:40334 IMAGE:5204222), complete cds.
AF044959 - Homo sapiens NADH:ubiquinone oxidoreductase NDUFS6 subunit mRNA, nuclear gene encoding mitochondrial protein, complete cds.
BC046155 - Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase), mRNA (cDNA clone MGC:57685 IMAGE:6047460), complete cds.
CR456880 - Homo sapiens full open reading frame cDNA clone RZPDo834B017D for gene NDUFS6, NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); complete cds, incl. stopcodon.
HQ257915 - Synthetic construct Homo sapiens clone IMAGE:100072224 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (NDUFS6), nuclear gene encoding mitochondria> (NDUFS6) gene, encodes complete protein.
KJ891683 - Synthetic construct Homo sapiens clone ccsbBroadEn_01077 NDUFS6 gene, encodes complete protein.
DQ584578 - Homo sapiens piRNA piR-51690, complete sequence.
JD251290 - Sequence 232314 from Patent EP1572962.
JD491354 - Sequence 472378 from Patent EP1572962.
JD427211 - Sequence 408235 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-3781 - aerobic respiration I (cytochrome c)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000274137.1, ENST00000274137.2, ENST00000274137.3, ENST00000274137.4, ENST00000274137.5, ENST00000274137.6, ENST00000274137.7, ENST00000274137.8, ENST00000274137.9, hCG_21432 , NDUFS6 , NM_004553, Q6IBC4, Q6IBC4_HUMAN, uc317jea.1, uc317jea.2
UCSC ID: ENST00000274137.10_4
RefSeq Accession: NM_004553.6
Protein: Q6IBC4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.