ID:NEDD8_HUMAN DESCRIPTION: RecName: Full=NEDD8; AltName: Full=Neddylin; AltName: Full=Neural precursor cell expressed developmentally down-regulated protein 8; Short=NEDD-8; AltName: Full=Ubiquitin-like protein Nedd8; Flags: Precursor; FUNCTION: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. SUBUNIT: Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53. SUBCELLULAR LOCATION: Nucleus. Note=Mainly nuclear. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. PTM: Cleavage of precursor form by UCHL3 or SENP8 is necessary for function. SIMILARITY: Belongs to the ubiquitin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15843
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0031625 ubiquitin protein ligase binding
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006464 cellular protein modification process GO:0006508 proteolysis GO:0006511 ubiquitin-dependent protein catabolic process GO:0006879 cellular iron ion homeostasis GO:0008104 protein localization GO:0009653 anatomical structure morphogenesis GO:0014070 response to organic cyclic compound GO:0016579 protein deubiquitination GO:0043687 post-translational protein modification GO:0045116 protein neddylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
