ID:ARHG8_HUMAN DESCRIPTION: RecName: Full=Neuroepithelial cell-transforming gene 1 protein; AltName: Full=Proto-oncogene p65 Net1; AltName: Full=Rho guanine nucleotide exchange factor 8; FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. SUBUNIT: Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Widely expressed. INDUCTION: By TGFB1. Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR). SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=AAB08847.1; Type=Frameshift; Positions=586; Sequence=AAB37683.1; Type=Frameshift; Positions=15, 33; Sequence=CAA08974.1; Type=Frameshift; Positions=8, 55, 59, 70, 586; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/NET1ID41526ch10p15.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z628
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001558 regulation of cell growth GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0035023 regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0051451 myoblast migration GO:0070301 cellular response to hydrogen peroxide GO:0071479 cellular response to ionizing radiation GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
